Evidence map›Paper›PMID 26262896›Full record

Trial reportPloS one2015

Prenatal Docosahexaenoic Acid Supplementation and Offspring Development at 18 Months: Randomized Controlled Trial.

Usha Ramakrishnan, Amanda Stinger, Ann M DiGirolamo, Reynaldo Martorell, Lynnette M Neufeld, Juan A Rivera, Lourdes Schnaas, Aryeh D Stein, Meng Wang

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00646360 (Effects of Prenatal DHA Supplements on Infant Development), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00646360 nacompletednot on this map

Effects of Prenatal DHA Supplements on Infant Development

TypeinterventionalSponsorEmory UniversityRan2005 to 2014Enrolled1,094ConditionsPregnancyArmsDHA, Placebo
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  5. Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Usha RamakrishnanEmory University, Atlanta, Georgia, United States of America.
Amanda StingerUniversity of Washington, Seattle, Washington, United States of America.
Ann M DiGirolamoGeorgia State University, Atlanta, Georgia, United States of America.
Reynaldo MartorellEmory University, Atlanta, Georgia, United States of America.
Lynnette M NeufeldGlobal Alliance for Improved Nutrition (GAIN), Geneva, Switzerland.
Juan A RiveraInstituto Nacional de Salud Publica, Cuernavaca, Mexico.
Lourdes SchnaasNational Institute of Perinatology, Mexico City, Mexico.
Aryeh D SteinEmory University, Atlanta, Georgia, United States of America.
Meng WangFamily Health International 360, Durham, North Carolina, United States of America.
Emory University · USFamily Health International 360 · USGeorgia State University · USGlobal Alliance for Improved Nutrition · CHInstituto Nacional de Perinatología · MXInstituto Nacional de Salud Pública · MXUniversity of Washington · US

Funding

Effect of Prenatal DHA Supplements on Infant DevelopmentR01HD043099 · NICHD · EMORY UNIVERSITY · PI RAMAKRISHNAN, USHA · 2004 to 2012
$4.1M
NICHD NIH HHS HD043099NICHD NIH HHS R01 HD043099
6 · The paper itself

Abstract

objectiveWe evaluated the effects of prenatal docosahexaenoic acid (DHA) supplementation on offspring development at 18 months of age.

designRandomized placebo double-blind controlled trial. SETTINGS: Cuernavaca, Mexico. PARTICIPANTS AND

methodsWe followed up offspring (n = 730; 75% of the birth cohort) of women in Mexico who participated in a trial of DHA supplementation during the latter half of pregnancy. We assessed the effect of the intervention on child development and the potential modifying effects of gravidity, gender, SES, and quality of the home environment. INTERVENTIONS OR MAIN EXPOSURES: 400 mg/day of algal DHA. OUTCOME MEASURES: Child development at 18 months of age measured using the Spanish version of the Bayley Scales of Infant Development-II. We calculated standardized psychomotor and mental development indices, and behavior rating scale scores.

resultsIntent-to-treat differences (DHA-control) were: Psychomotor Developmental Index -0.90 (95% CI: -2.35, 0.56), Mental Developmental Index -0.26 (95% CI: -1.63, 1.10) and Behavior Rating Scale -0.01 (95% CI: -0.95, 0.94). Prenatal DHA intake attenuated the positive association between home environment and psychomotor development index observed in the control group (p for interaction = 0.03) suggesting potential benefits for children living in home environments characterized by reduced caregiver interactions and opportunities for early childhood stimulation.

conclusionsPrenatal DHA supplementation in a population with low intakes of DHA had no effects on offspring development at 18 months of age although there may be some benefit for infants from poor quality home environments.

trial registrationClinicaltrials.gov NCT00646360.

Indexed as

Dietary SupplementsMaternal ExposurePrenatal Exposure Delayed EffectsChild DevelopmentDocosahexaenoic AcidsFemaleHumansInfantMexicoPregnancyPsychomotor PerformanceDocosahexaenoic Acids

Identifiers

PMID26262896
PMCPMC4532364
OpenAlexW1950071498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.