ArticlePloS one2015
A Multi-Breed Genome-Wide Association Analysis for Canine Hypothyroidism Identifies a Shared Major Risk Locus on CFA12.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Repeated thyroid function evaluations in the dog: a retrospective study of 8,309 dogs.Frontiers in veterinary science · 2025Article
- BRASS: Permutation methods for binary traits in genetic association studies with structured samples.PLoS genetics · 2023Article
- Laboratory indicators of hypothyroidism and TgAA-positivity in the Eurasian dog breed.PloS one · 2023Article
- Frequency, breed predispositions and other demographic risk factors for diagnosis of hypothyroidism in dogs under primary veterinary care in the UK.Canine medicine and genetics · 2022Article
- Breed distributions for diabetes mellitus and hypothyroidism in Norwegian dogs.Canine medicine and genetics · 2022Article
- Heterogeneity of a dwarf phenotype in Dutch traditional chicken breeds revealed by genomic analyses.Evolutionary applications · 2021Article
- Review
- Association of Common Genetic Variants in theGenes · 2020Article
- Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs.BMC genomics · 2020Article
- Swedish Experiences From 60 Years of Screening and Breeding Programs for Hip Dysplasia-Research, Success, and Challenges.Frontiers in veterinary science · 2020Review
- Primary closed angle glaucoma in the Basset Hound: Genetic investigations using genome-wide association and RNA sequencing strategies.Molecular vision · 2019Article
- Heritability of hypothyroidism in the Finnish Hovawart population.Acta veterinaria Scandinavica · 2016Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothyroidism is a complex clinical condition found in both humans and dogs, thought to be caused by a combination of genetic and environmental factors. In this study we present a multi-breed analysis of predisposing genetic risk factors for hypothyroidism in dogs using three high-risk breeds--the Gordon Setter, Hovawart and the Rhodesian Ridgeback. Using a genome-wide association approach and meta-analysis, we identified a major hypothyroidism risk locus shared by these breeds on chromosome 12 (p = 2.1x10(-11)). Further characterisation of the candidate region revealed a shared ~167 kb risk haplotype (4,915,018-5,081,823 bp), tagged by two SNPs in almost complete linkage disequilibrium. This breed-shared risk haplotype includes three genes (LHFPL5, SRPK1 and SLC26A8) and does not extend to the dog leukocyte antigen (DLA) class II gene cluster located in the vicinity. These three genes have not been identified as candidate genes for hypothyroid disease previously, but have functions that could potentially contribute to the development of the disease. Our results implicate the potential involvement of novel genes and pathways for the development of canine hypothyroidism, raising new possibilities for screening, breeding programmes and treatments in dogs. This study may also contribute to our understanding of the genetic etiology of human hypothyroid disease, which is one of the most common endocrine disorders in humans.
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