Evidence map›Paper›PMID 26261886›Full record

ArticleTranslational psychiatry2015

Lack of association between type 2 diabetes and major depression: epidemiologic and genetic evidence in a multiethnic population.

Z Samaan, S Garasia, H C Gerstein, J C Engert, V Mohan, R Diaz, S S Anand, D Meyre

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Comorbid depression in medical diseases.Nature reviews. Disease primers · 2020
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2017
    Article
  17. Observational
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Z Samaan1] Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada [2] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [3] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada.
S GarasiaDepartment of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada.
H C Gerstein1] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [2] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada [3] Department of Medicine, McMaster University, Hamilton, ON, Canada.
J C EngertDepartment of Medicine, McGill University, Montreal, QC, Canada.
V MohanMadras Diabetes Research Foundation, Chennai, India.
R DiazECLA Academic Research Organization, Rosario, Argentina.
S S Anand1] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [2] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada [3] Department of Medicine, McMaster University, Hamilton, ON, Canada.
D Meyre1] Department of Clinical Epidemiology and Biostatistics, Michael DeGroote Centre for Learning and Discovery, McMaster University, Hamilton, ON, Canada [2] Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton General Hospital, Hamilton, ON, Canada [3] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.
McMaster University · CAEstudios Clínicos Latinoamérica · ARHamilton Health Sciences · CAMadras Diabetes Research Foundation · INMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The positive association between depression and type 2 diabetes (T2D) has been controversial, and little is known about the molecular determinants linking these disorders. Here we investigated the association between T2D and depression at the clinical and genetic level in a multiethnic cohort. We studied 17,404 individuals from EpiDREAM (3209 depression cases and 14,195 controls) who were at risk for T2D and had both phenotypic and genotypic information available at baseline. The glycemic status was determined using the 2003 American Diabetes Association criteria and an oral glucose tolerance test. Major depressive episode during the previous 12 months was diagnosed using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnostic criteria. Twenty single-nucleotide polymorphisms (SNPs) previously associated with T2D were genotyped using the cardiovascular gene-centric 50-K SNP array and were analyzed separately and in combination using an unweighted genotype score (GS). Multivariate logistic regression models adjusted for age, sex, ethnicity and body mass index were performed. Newly diagnosed impaired fasting glucose (IFG)/impaired glucose tolerance (IGT), T2D and dysglycemia status were not associated with major depression (0.30 ⩽ P ⩽ 0.65). Twelve out of twenty SNPs and the GS were associated with IFG/IGT, T2D and/or dysglycemia status (6.0 × 10(-35) ⩽ P ⩽ 0.048). In contrast, the 20 SNPs and GS were not associated with depression (P ⩾ 0.09). Our cross-sectional data do not support an association between T2D and depression at the clinical and genetic level in a multiethnic population at risk for T2D.

Indexed as

AdolescentAdultAgedAged, 80 and overBlood GlucoseCohort StudiesComorbidityCross-Sectional StudiesDiabetes Mellitus, Type 2EthnicityFemaleGenetic Predisposition to DiseaseHumansLongitudinal StudiesMajor Depressive DisorderMaleBlood Glucose

Identifiers

PMID26261886
PMCPMC4564566
OpenAlexW2205977753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.