ArticleAdvanced biomedical research2015
Expression of prostaglandin I2 (prostacyclin) receptor in blood of migraine patients: A potential biomarker.
Article in Advanced biomedical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Migraine with Brainstem Aura Accompanied by Disorders of Consciousness.Journal of pain research · 2021Review
- Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine.Frontiers in molecular neuroscience · 2021Article
- Variants in Human Prostacyclin Receptor Gene in Patients with Migraine Headache.Iranian journal of psychiatry · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMigraine is the most common chronic neurological disorders that may be associated with vasodilatation. According to the role of prostaglandin I2 (prostacyclin) receptor (PTGIR) in migraine as a receptor, which acts in vasodilatation, we decided to study the changes of PTGIR expression in migraine patients in relation to a suitable control group. MATERIALS AND
methodsExtracted mRNA from lymphocytes of 50 cases and 50 controls was used to synthesize cDNA. Real-time polymerase chain reaction was performed, and the data were analyzed. Our results show that PTGIR mRNA expression in cases was significantly higher than the control group (P = 0.010).
resultsIn conclusion, mRNA expression of PTGIR in the blood of people with migraines could be considered as a biomarker.
conclusionIn addition, repression of PTGIR gene expression by methods such as using siRNA is probably suitable for therapy of migraine patients.
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