ReviewWorld journal of critical care medicine2015
Severe scrub typhus infection: Clinical features, diagnostic challenges and management.
Review in World journal of critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Unveiling the burden of scrub typhus in acute febrile illness cases across India: A systematic review & meta-analysis.The Indian journal of medical research · 2024Pooled it
- Comparative effectiveness of azithromycin for treating scrub typhus: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2017Pooled it
- Coronary artery lesions in pediatric scrub typhus: A case series from Guangzhou, China.PLoS neglected tropical diseases · 2026Article
- Scrub Typhus Presenting with Isolated Xerostomia.The American journal of tropical medicine and hygiene · 2026Article
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- Corneal injury associated with scrub typhus following mite exposure in a child in Taiwan: a case report.Journal of medical case reports · 2026Article
- Article
- Review
- Article
- Diagnostic Value of Neutrophil CD64 in Differentiating Scrub Typhus From Febrile Diseases.Immunity, inflammation and disease · 2026Article
- A humanized IFN-γ mouse model reveals skin eschar formation, enhanced susceptibility and scrub typhus pathogenesis.PLoS pathogens · 2026Article
- Advancing the diagnosis of scrub typhus with targeted next-generation sequencing.Frontiers in microbiology · 2026Article
- Evaluation of Oral Doxycycline, Azithromycin, or Sequential Doxycycline-Azithromycin Treatment for Scrub Typhus.Mediterranean journal of hematology and infectious diseases · 2026Article
- Case Report: An imported severe case of paediatric scrub typhus with Karp B subgenotype in non-endemic Northern China, Beijing.Frontiers in pediatrics · 2026Article
- Severe paediatric scrub typhus with complications: a case report and literature review.BMC pediatrics · 2025Review
- Neglected and lethal: Case series of fatal scrub typhus in Malaysia.PLoS neglected tropical diseases · 2025Article
- Beyond the infection: mapping the risk of cardiovascular events post-scrub typhus in a nationwide cohort study.Emerging microbes & infections · 2025Article
- A Rare and Severe Multisystem Cascade of AKI, ARDS, and Septic Shock Leading to Acalculous Cholecystitis in a Young Scrub Typhus Patient: A Case Report From Nepal.Clinical case reports · 2025Article
- Clinical and laboratory factors associated with scrub typhus and hemorrhagic fever with renal syndrome in Southwestern Korea: A cross-sectional study.PLoS neglected tropical diseases · 2025Article
- Severe Scrub Typhus Presenting With Multiorgan Dysfunction and Atypical Features: Two Case Reports From the Maldives.Cureus · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis. About a third of patients admitted to hospital with scrub typhus infection have evidence of organ dysfunction that may include respiratory failure, circulatory shock, mild renal or hepatic dysfunction, central nervous system involvement or hematological abnormalities. Since the symptoms and signs are non-specific and resemble other tropical infections like malaria, enteric fever, dengue or leptospirosis, appropriate laboratory tests are necessary to confirm diagnosis. Serological assays are the mainstay of diagnosis as they are easy to perform; the reference test is the indirect immunofluorescence assay (IFA) for the detection of IgM antibodies. However in clinical practice, the enzyme-linked immuno-sorbent assay is done due to the ease of performing this test and a good sensitivity and sensitivity when compared with the IFA. Paired samples, obtained at least two weeks apart, demonstrating a ≥ 4 fold rise in titre, is necessary for confirmation of serologic diagnosis. The mainstay of treatment is the tetracycline group of antibiotics or chloramphenicol although macrolides are used alternatively. In mild cases, recovery is complete. In severe cases with multi-organ failure, mortality may be as high as 24%.
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