ArticleInternational journal of clinical and experimental pathology2015
Atrophic dermatofibrosarcoma protuberans with the fusion gene COL1A1-PDGFB detected by RT-PCR using only a single primer pair.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Atrophic dermatofibrosarcoma protuberans: Two case reports and literature review.Frontiers in oncology · 2023Article
- Pediatric atrophic dermatofibrosarcoma protuberans.Pediatric investigation · 2017Article
- Congenital atrophic dermatofibrosarcoma protuberans detected by COL1A1-PDGFB rearrangement.Diagnostic pathology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
Dermatofibrosarcoma protuberans (DFSPs) is an uncommon dermal tumor of intermediate to low-grade malignancy. A few patients have clinically persistent plaques that might be atrophic, and they are difficult to be diagnosed clinically. With the development of cytogenetic and molecular biology techniques, the detection of fusion transcripts of the collagen type 1a1 (COL1A1) and platelet-derived growth factor-BB (PDGFB) genes has been recognized as a reliable and valuable molecular tool for the diagnosis of DFSPs. We reported a 24-year-old woman who had a 2 years history of atrophic DFSPs, and detected the gene fusion between COL1A1 to PDGFB by one-step method of RT-PCR using only a single primer pair. The gene fusion detected by this rapid and efficient one-step method in our patient appears to be the first report of atrophic DFSPs, and we detected a novel COL1A1 breakpoint between exon 2 and exon 3.
Indexed as
Identifiers
26261653PMC4525987W1168204484What OpenQuestion holds
Registered trials
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