ArticleInternational journal of clinical and experimental pathology2015
Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma risk.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Application of contrast-enhanced ultrasound and enhanced CT in diagnosis of liver cancer and evaluation of radiofrequency ablation.Oncology letters · 2018Article
- XRCC1 and XPD polymorphisms and their relation to the clinical course in hepatocarcinoma patients.Oncology letters · 2017Article
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Authors and funding
5 authors.
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Abstract
purposeWe carried out this study to find out the relevance between rs2281388 T/C polymorphism of human leukocyte antigen (HLA) gene and hepatocellular carcinoma (HCC) risk in Chinese Han population.
methodsThe method of polymerase chain reaction (PCR) was applied to amplify the genomic DNA. Then the PCR products were sequenced to test the HLA-DP gene rs2281388T/C polymorphism of the case and control groups. Odds ratios (ORs) and 95% confidence interval (95% CIs) were utilized to evaluate the potential correlation between rs2281388 variants and HCC risk.
resultsWe analyzed the rs2281388 polymorphism distribution among the clinical pathological features. The results showed that there existed a significant statistic correlation between rs2281388T/C polymorphism of HLA-DP gene and HBsAg feature, and no significant correlation was found between rs2281388 and other clinical features. Further analysis showed that the TT genotype of rs2281388 was significantly correlated with HCC risk, and the same to T allele, but there was no significant difference of CT genotype distribution in case and control groups.
conclusionTT genotype and T allele of HLA-DP gene rs2281388 polymorphism may increase the risk of HCC.
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26261648PMC4525982What OpenQuestion holds
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