ArticleInternational journal of clinical and experimental pathology2015
Polymorphisms and phenotypic analysis of cytochrome P450 3A4 in the Uygur population in northwest China.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Effect of patient genetics on etonogestrel pharmacokinetics when combined with efavirenz or nevirapine ART.The Journal of antimicrobial chemotherapy · 2019Trial
- Article
- Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.PloS one · 2023Article
- Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer.Endocrinology and metabolism (Seoul, Korea) · 2022Review
- A probability formula derived from serum indicators, age, and comorbidities as an early predictor of dementia in elderly Chinese people.Brain and behavior · 2021Article
- Discovery and validation of FBLN1 and ANT3 as potential biomarkers for early detection of cervical cancer.Cancer cell international · 2021Article
- Population Genetic Difference of Pharmacogenomic VIP Variants in the Tibetan Population.Pharmacogenomics and personalized medicine · 2021Article
- Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.Molecular genetics & genomic medicine · 2019Article
- The impact of genetic variants in IL1R2 on cervical cancer risk among Uygur females from China: A case-control study.Molecular genetics & genomic medicine · 2019Article
- Genotype and Allele Frequency ofTurkish journal of pharmaceutical sciences · 2018Article
- A Novel Multiplex PCR-RFLP Method for Simultaneous Genotyping ofThe Malaysian journal of medical sciences : MJMS · 2018Article
- Observational
- Genetic polymorphism analysis of cytochrome P4502E1 (CYP2E1) in a Chinese Tibetan population.Medicine · 2017Article
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8 authors.
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Abstract
purposeGenetic polymorphisms in CYP3A4 can change its activity to a certain degree, thus leading to differences among different populations in drug efficacy or adverse drug reactions.
methodsThe study was intended to validate the genetic polymorphisms in CYP3A4 in Uygur Chinese population, we sequenced and screened for genetic variants including 5'UTR, promoters, exons, introns, and 3'UTR region of the whole CYP3A4 gene in 100 unrelated, healthy.
resultsTwenty-one genetic polymorphisms in CYP3A4, and nine of them were novel. We detected CYP3A4*8, a putative poor-metabolizer allele, with the frequency of 0.5% in Uygur population. Tfsitescan revealed that the density of transcription factor varied in the different promoter regions, among which some were key regions for transcription factor binding.
conclusionour results provide basic information about CPY3A4 alleles in Uygur and suggest that the enzymatic activities of CPY3A4 may differ among the diverse ethnic populations of China.
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