Conserved hypothetical protein Rv1977 in Mycobacterium tuberculosis strains contains sequence polymorphisms and might be involved in ongoing immune evasion.

Yi Jiang, Haican Liu, Xuezhi Wang, Guilian Li, Yan Qiu, Xiangfeng Dou, Kanglin Wan

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Mycobacterium tuberculosis MEM39 (Rv1977) hijacks host aldolase A (ALDOA) to subvert immunometabolism to facilitate bacterial intracellular survival.Cellular & molecular immunology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yi JiangState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, P. R. China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003, China.

Haican LiuState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, P. R. China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003, China.

Xuezhi WangState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, P. R. China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003, China.

Guilian LiState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, P. R. China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003, China.

Yan QiuState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, P. R. China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003, China.

Xiangfeng DouBeijing Center for Diseases Prevention and Control Beijing 100013, China.

Kanglin WanState Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention Beijing 102206, P. R. China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Hangzhou 310003, China.

Chinese Center For Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Host immune pressure and associated parasite immune evasion are key features of host-pathogen co-evolution. A previous study showed that human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved and thus it was deduced that M. tuberculosis lacks antigenic variation and immune evasion. Here, we selected 151 clinical Mycobacterium tuberculosis isolates from China, amplified gene encoding Rv1977 and compared the sequences. The results showed that Rv1977, a conserved hypothetical protein, is not conserved in M. tuberculosis strains and there are polymorphisms existed in the protein. Some mutations, especially one frameshift mutation, occurred in the antigen Rv1977, which is uncommon in M.tb strains and may lead to the protein function altering. Mutations and deletion in the gene all affect one of three T cell epitopes and the changed T cell epitope contained more than one variable position, which may suggest ongoing immune evasion.

Indexed as

Frameshift MutationPolymorphism, GeneticAmino Acid SequenceAntigens, BacterialBacterial ProteinsChinaEpitopes, T-LymphocyteGene Expression Regulation, BacterialGenotypeHost-Pathogen InteractionsHumansImmune EvasionMolecular Sequence DataMycobacterium tuberculosisPhenotypeTuberculosisAntigens, BacterialBacterial ProteinsEpitopes, T-Lymphocyteimmune evasionMycobacterium tuberculosisRv1977

Identifiers

PMID26261576

PMCPMC4525910

OpenAlexW2460455675

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.