ArticleInternational journal of clinical and experimental pathology2015
Aberrant LRP16 protein expression in primary neuroendocrine lung tumors.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- MacroD1 sustains mitochondrial integrity and oxidative metabolism.Nature communications · 2025Article
- ADP-ribose hydrolases: biological functions and potential therapeutic targets.Expert reviews in molecular medicine · 2024Review
- The Controversial Roles of ADP-Ribosyl Hydrolases MACROD1, MACROD2 and TARG1 in Carcinogenesis.Cancers · 2020Review
- (ADP-ribosyl)hydrolases: structure, function, and biology.Genes & development · 2020Review
- Article
- Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Multiple Roles for Mono- and Poly(ADP-Ribose) in Regulating Stress Responses.Trends in genetics : TIG · 2019Review
- LRP16 prevents hepatocellular carcinoma progression through regulation of Wnt/β-catenin signaling.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Leukemia-related protein 16 (LRP16) promotes tumor growth and metastasis in pancreatic cancer.OncoTargets and therapy · 2018Article
- GDF11 restrains tumor growth by promoting apoptosis in pancreatic cancer.OncoTargets and therapy · 2018Article
- MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Leukemia related protein 16 gene (LRP16) localized on chromosome 11q12.1, is an important estrogen-responsive gene and a crucial regulator for NF-kB activation. LRP16 is frequently expressed in human cancers; however, the LRP16 gene remains unexplored in lung neuroendocrine tumors. The aim of this study was to investigate the role of LRP16 expression in primary lung neuroendocrine tumors.
methodslung neuroendocrine tumors were analyzed for LRP16 gene expression by two-step non-biotin immunohistochemical method.
resultsFifty of ninety (55.6%) cases of neuroendocrine lung tumors tested were positive for LRP16 protein by immunohistochemistry. The expression of LRP16 was mainly located in cytoplasm and nucleus of tumor cells. LRP16 protein was corresponding to tumor type and clinical stage, as well as survival time.
conclusionsThe results indicate that abnormal LRP16 expression is noted in neuroendocrine lung tumors and the expression can give insight into the pathogenesis of the disease. The LRP16 protein may serve as a potential marker in predicting prognosis of neuroendocrine lung tumors.
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Identifiers
26261536PMC4525870W1487033997What OpenQuestion holds
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