ArticleInternational journal of clinical and experimental pathology2015
Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats: a histological and immunohisochemical study.
Article in International journal of clinical and experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy.International journal of molecular sciences · 2024Pooled it
- Protective and Therapeutic Effects of Lactic Acid Bacteria against Aflatoxin B1 Toxicity to Rat Organs.Microorganisms · 2023Article
- High-pressure acidified steaming with varied citric acid dosing can successfully detoxify mycotoxins.Food science & nutrition · 2023Article
- Antifungal Activity ofJournal of functional biomaterials · 2023Article
- Curcumin ameliorated low dose-Bisphenol A induced gastric toxicity in adult albino rats.Scientific reports · 2022Article
- Alleviation of Oral Exposure to Aflatoxin B1-Induced Renal Dysfunction, Oxidative Stress, and Cell Apoptosis in Mice Kidney by Curcumin.Antioxidants (Basel, Switzerland) · 2022Article
- Protective effects of methanolic leaf extracts of Monanthotaxis caffra against aflatoxin B1-induced hepatotoxicity in rats.The Onderstepoort journal of veterinary research · 2022Article
- The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study.BMC pharmacology & toxicology · 2022Article
- Descriptive Histopathological and Ultrastructural Study of Hepatocellular Alterations Induced by Aflatoxin B1 in Rats.Animals : an open access journal from MDPI · 2021Article
- Abnormal steroidogenesis, oxidative stress, and reprotoxicity following prepubertal exposure to butylparaben in mice and protective effect of Curcuma longa.Environmental science and pollution research international · 2021Article
- Health Benefits of Turmeric and Curcumin Against Food Contaminants.Advances in experimental medicine and biology · 2021Review
- Comparative consequences of two sources of aflatoxins in ducklings experimental aflatoxicosis.Veterinary research forum : an international quarterly journal · 2021Article
- Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats.BMC nephrology · 2019Article
- Evaluation of emerging biomarkers of renal damage and exposure to aflatoxin-BEnvironmental science and pollution research international · 2019Article
- Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAflatoxin contamination of foods is a worldwide problem. Chronic aflatoxin exposure is associated with kidney damage. Curcumin is a herbal agent, used in medicine with a wide range of beneficial therapeutic effects.
objectiveto evaluate the effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats. MATERIALS AND
methodsForty adult male rats were included and they were divided equally into 4 groups (10 rats each): Group I (control group), group II (Curcumin group): The rats received curcumin (200 mg/kg b.w.) orally by gastric tube for 5 days/week, group III (Aflatoxin B1 group): The rats received aflatoxin B1 (250 μg/kg b.w./day) orally by gastric tube 5 days/week for 4 weeks, group IV (Aflatoxin B1 and Curcumin group): The rats received aflatoxin and curcumin orally by gastric tube 5 days/week for 4 weeks. Kidney specimens were prepared and sections were stained with hematoxylin and eosin, Masson's trichrome, Periodic acid Schiff, immunohistochemical detection of desmin and Bcl2.
resultsThe tubules of group III showed degenerative and necrotic changes with disruption of basal lamina. There was a significant decrease Bcl2 expression in the tubules, but the glomeruli showed an enlargement with dilation of their capillaries lumina in some areas, while the other areas showed glomerular atrophy with obliteration of their capillaries lumina. There was a significant increase in desmin expression in the glomerular cells. The interstitium showed hemorrhage and cellular infiltration. Group IV showed improvement of the histological and immunohistochemical changes described before.
conclusionAflatoxin B1 has deleterious effects of on the histological structure of the rat's renal cortex and curcumin minimized these effects as it has antioxidant, anti-inflammatory and antiapoptotic activities. We advise eating nutritious diets that contain sufficient amounts of curcumin and regulation must implement to avoid the presence of aflatoxins in high concentrations in human food.
Indexed as
Identifiers
26261479PMC4525813W2415757843What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.