ReviewCold Spring Harbor perspectives in biology2015
The Influence of Genome and Cell Size on Brain Morphology in Amphibians.
Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Exploring Larval Axolotl Brain Development: Insights Into Developmental and Functional Constraints.Evolution & development · 2026Article
- Ploidy and neuron size impact nervous system development and function in Xenopus.Cell reports · 2026Article
- Parallel Morphological and Functional Development in the Xenopus Retinotectal System.Developmental neurobiology · 2026Article
- Amphibian Segmentation Clock Models Suggest How Large Genome and Cell Sizes Slow Developmental Rate.Integrative organismal biology (Oxford, England) · 2024Article
- Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023Review
- Ontogeny of the middle ear and auditory sensitivity in the Natterjack toad (Epidalea calamita).The Journal of experimental biology · 2022Article
- Genome size drives morphological evolution in organ-specific ways.Evolution; international journal of organic evolution · 2022Article
- Hearing without a tympanic ear.The Journal of experimental biology · 2022Review
- Recovery-from-extinction effects in an anuran amphibian: renewal effect, but no reinstatement.Animal cognition · 2022Article
- MRI- and histologically derived neuroanatomical atlas of the Ambystoma mexicanum (axolotl).Scientific reports · 2021Article
- Study of Natural Longlife Juvenility and Tissue Regeneration in Caudate Amphibians and Potential Application of Resulting Data in Biomedicine.Journal of developmental biology · 2021Review
- What the salamander eye has been telling the vision scientist's brain.Seminars in cell & developmental biology · 2020Review
- Organelle size scaling over embryonic development.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- The power of amphibians to elucidate mechanisms of size control and scaling.Experimental cell research · 2020Review
- Genetic Code Optimization for Cotranslational Protein Folding: Codon Directional Asymmetry Correlates with Antiparallel Betasheets, tRNA Synthetase Classes.Computational and structural biotechnology journal · 2017Article
- Cell-Size Control.Cold Spring Harbor perspectives in biology · 2016Review
- Convergent evolution of complex brains and high intelligence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Biological Scaling Problems and Solutions in Amphibians.Cold Spring Harbor perspectives in biology · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In amphibians, nerve cell size is highly correlated with genome size, and increases in genome and cell size cause a retardation of the rate of development of nervous (as well as nonnervous) tissue leading to secondary simplification. This yields an inverse relationship between genome and cell size on the one hand and morphological complexity of the tectum mesencephali as the main visual center, the size of the torus semicircularis as the main auditory center, the size of the amphibian papilla as an important peripheral auditory structure, and the size of the cerebellum as a major sensorimotor center. Nervous structures developing later (e.g., torus and cerebellum) are more affected by secondary simplification than those that develop earlier (e.g., the tectum). This effect is more prominent in salamanders and caecilians than in frogs owing to larger genome and cells sizes in the former two taxa. We hypothesize that because of intragenomic evolutionary processes, important differences in brain morphology can arise independently of specific environmental selection.
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Registered trials
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