Evidence map›Paper›PMID 26261221›Full record

ArticleNeuro-oncology2016

Rates and risks for late referral to hospice in patients with primary malignant brain tumors.

Eli L Diamond, David Russell, Maria Kryza-Lacombe, Kathryn H Bowles, Allison J Applebaum, Jeanne Dennis, Lisa M DeAngelis, Holly G Prigerson

Open access · bronzeAbstract read
In one paragraph

Article in Neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Pattern of care of brain tumor patients in the last months of life: analysis of a cohort of 3045 patients in the last 10 years.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
  6. Review
  7. Article
  8. Effect of the COVID-19 Pandemic on Place of Death Among Medicaid and Commercially Insured Patients With Cancer in Washington State.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
  9. Article
  10. A retrospective chart review to identify the involvement of palliative care with glioblastoma multiforme patients.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2023
    Article
  11. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2023
    Article
  12. Article
  13. Disparities in place of death for patients with primary brain tumors and brain metastases in the USA.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  14. Neuro-oncology and supportive care: the role of the neurologist.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
  15. Patient Factors Associated with Different Hospice Programs in Korea: Analyzing Healthcare Big Data.International journal of environmental research and public health · 2022
    Article
  16. Observational
  17. Article
  18. Ethics consultations in neuro-oncology.Neuro-oncology practice · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Eli L DiamondDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
David RussellDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
Maria Kryza-LacombeDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
Kathryn H BowlesDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
Allison J ApplebaumDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
Jeanne DennisDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
Lisa M DeAngelisDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
Holly G PrigersonDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York (E.L.D., M.K-L., L.M.D.); Center for Research on End of Life Care, Weill Cornell Medical College, New York, New York (E.L.D., H.G.P.); Center for Home Care Policy and Research, Visiting Nurse Service of New York, New York, New York (D.R., K.H.B.); Center for Integrative Science in Aging, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania (K.H.B.); Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York (A.J.A.); VNSNY Hospice Care, Visiting Nurse Service of New York, New York (J.D.).
University of Pennsylvania · USVisiting Nurse Service of New York · USCornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundPrimary malignant brain tumors (PMBTs) are devastating malignancies with poor prognosis. Optimizing psychosocial and supportive care is critical, especially in the later stages of disease.

methodsThis retrospective cohort study compared early versus late hospice enrollment of PMBT patients admitted to the home hospice program of a large urban, not-for-profit home health care agency between 2009 and 2013.

resultsOf 160 patients with PMBT followed to death in hospice care, 32 (22.5%) were enrolled within 7 days of death. When compared with patients referred to hospice more than 7 days before death, a greater proportion of those with late referral were bedbound at admission (97.2% vs 61.3%; OR=21.85; 95% CI, 3.42-919.20; P < .001), aphasic (61.1% vs 20.2%; OR = 6.13; 95% CI, 2.59-15.02; P < .001), unresponsive (38.9% vs 4%; OR = 14.76,;95% CI, 4.47-57.98; P < .001), or dyspneic (27.8% vs 9.7%; OR = 21.85; 95% CI, 3.42-10.12; P = .011). In multivariable analysis, male patients who were receiving Medicaid or charitable care and were without a health care proxy were more likely to enroll in hospice within 1 week of death.

conclusionsLate hospice referral in PMBT is common. PMBT patients enrolled late in hospice are severely neurologically debilitated at the time hospice is initiated and therefore may not derive optimal benefit from multidisciplinary hospice care. Men, patients with lower socioeconomic status, and those without a health care proxy may be at risk for late hospice care and may benefit from proactive discussion about end-of-life care in PMBT, but prospective studies are needed.

Indexed as

Referral and ConsultationAgedBrain NeoplasmsCohort StudiesFemaleHome Care ServicesHospice CareHumansMaleMiddle AgedRetrospective StudiesRisk Factorsglioblastomamalignant brain tumorpalliative carequality of life

Identifiers

PMID26261221
PMCPMC4677417
OpenAlexW2214924484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.