ArticleThe Indian journal of medical research2015
Drug-induced diseases (DIDs): An experience of a tertiary care teaching hospital from India.
Article in The Indian journal of medical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Impact of met-haemoglobin and oxidative stress on endothelial function in patients with transfusion dependent β-thalassemia.Scientific reports · 2024Article
- Drug-food Interactions in the Era of Molecular Big Data, Machine Intelligence, and Personalized Health.Recent advances in food, nutrition & agriculture · 2022Review
- Drug-induced diseases (DIDs).The Indian journal of medical research · 2016Article
- Authors' response.The Indian journal of medical research · 2016Article
- Age, gender & co-morbidities as risk factors for drug-induced diseases.The Indian journal of medical research · 2015Article
- Drug induced diseases (DID): Need for more awareness & research.The Indian journal of medical research · 2015Article
Corrections and comments
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- Erratum issuedErratum.2016
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesDrug-induced diseases (DIDs) are well known but least studied. Data on DIDs from India are not available. Hence, this retrospective cross-sectional study was undertaken using suspected adverse drug reaction (ADR) data collected form Pharmacovigilance Programme of India (PvPI) to evaluate profile of DIDs over two years, in a tertiary care teaching hospital from north India.
methodsThe suspected ADRs in the form of DID were evaluated for drug and disease related variables and were classified in terms of causality.
resultsDID rate was 38.80 per cent. Mean duration of developing DIDs was 26.05 ± 9.6 days; 25.16 per cent had more than one co-morbid condition. Geriatric population (53.99%) accounted for maximum DIDs followed by adult (37.79%) and paediatric (8.21%). Maximum events were probable (93.98%) followed by possible (6.04%). All DIDs required intervention. Gastritis (7.43%), diarrhoea (5.92%), anaemia (4.79%), hypotension (2.77%), hepatic dysfunction (2.69%), hypertension (1.51%), myalgia (1.05%), and renal dysfunction (1.01%) were some of the DIDs. Anti tubercular treatment (ATT), anti retroviral treatment (ART), ceftriaxone injection, steroids, non-steroidal anti-inflammatory drugs, antimicrobials and anticancer drugs were found as commonly offending drugs. INTERPRETATION &
conclusionsOur findings show that DIDs are a significant health problem in our country, which need more attention.
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