Evidence map›Paper›PMID 26260979›Full record

ArticleLung2015

Exhaled Breath Condensate pH in Lung Cancer, the Impact of Clinical Factors.

Andras Bikov, Zsofia Lazar, Nora Gyulai, Marton Szentkereszty, Gyorgy Losonczy, Ildiko Horvath, Gabriella Galffy

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Development of Optimized, Inhalable, Gemcitabine-Loaded Gelatin Nanocarriers for Lung Cancer.Journal of aerosol medicine and pulmonary drug delivery · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Andras BikovDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary. andras.bikov@gmail.com.
Zsofia LazarDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
Nora GyulaiDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
Marton SzentkeresztyDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
Gyorgy LosonczyDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
Ildiko HorvathDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
Gabriella GalffyDepartment of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest, 1125, Hungary.
Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLung cancer may be associated with airway acidification due to enhanced airway inflammation and oxidative stress. Exhaled breath condensate (EBC) pH is a non-invasive indicator of airway acidity; however, it is still unclear how EBC pH changes in lung cancer. The aim of the study was to investigate EBC pH in lung cancer together with clinical variables.

methodsThirty-five patients with lung cancer and 37 control subjects (21 patients with stable COPD and 16 non-COPD smokers) were enrolled. EBC was collected for pH, which was determined with the argon-purging method, compared among the groups and correlated with clinical variables of patients with lung cancer.

resultsNo difference was found in EBC pH between patients with lung cancer and control subjects. However, endobronchial tumour localisation, squamous-cell carcinoma subtype and gastro-oesophageal reflux were associated with low EBC pH values. No relationship was observed between EBC pH and the presence of COPD, lung function variables or smoking history.

conclusionsAlthough, EBC pH is unchanged in lung cancer, lower EBC pH values are associated with distinct phenotypes. Our findings could facilitate further research on airway acidity in lung cancer.

Indexed as

AdenocarcinomaAgedBreath TestsCarcinoma, Squamous CellCase-Control StudiesComorbidityFemaleGastroesophageal RefluxHumansHydrogen-Ion ConcentrationLung NeoplasmsMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSmall Cell Lung CarcinomaSmokingAirway acidityBiomarkersBreath testExhaled breath condensateLung cancer

Identifiers

PMID26260979
OpenAlexW1176398300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.