Trial reportBMC cardiovascular disorders2015
Validation of the VEINES-QOL quality of life instrument in venous leg ulcers: repeatability and validity study embedded in a randomised clinical trial.
Trial report in BMC cardiovascular disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04714749 (Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility and Tolerance Study for the Treatment of Varicose Ulcers by Cyanoacrylate Glue
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Investigating quality of life instrument measurement properties for adults with active venous leg ulcers: A systematic review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Pooled it
- Compression therapies for venous leg ulcers: The VENous Ulcer Study 6 (VenUS 6), an open, multicentre, randomised clinical trial.PLoS medicine · 2026Trial
- Endovascular Therapy for Post-Thrombotic Syndrome - A Randomized Trial.The New England journal of medicine · 2026Trial
- A randomized clinical trial of isolated ambulatory phlebectomy versus saphenous thermal ablation with concomitant phlebectomy (SAPTAP Trial).The British journal of surgery · 2023Trial
- CAVA (Ultrasound-Accelerated Catheter-Directed Thrombolysis on Preventing Post-Thrombotic Syndrome) Trial: Long-Term Follow-Up Results.Journal of the American Heart Association · 2021Trial
- Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis.Journal of vascular surgery. Venous and lymphatic disorders · 2020Trial
- [Diagnosis and treatment of varicose veins].Dermatologie (Heidelberg, Germany) · 2026Review
- Factors Associated With Quality of Life in Patients With Venous Leg Ulcers in a Community Setting: A Cross-Sectional Study.Health science reports · 2025Article
- A state-of-the-art review of quality-of-life assessment in venous disease.Journal of vascular surgery. Venous and lymphatic disorders · 2024Review
- Quality of life in oncological patients with venous thromboembolic disease.Research and practice in thrombosis and haemostasis · 2024Review
- Polidocanol-foam treatment of varicose veins: Quality-of-life impact compared to conventional surgery.Clinics (Sao Paulo, Brazil) · 2024Observational
- Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older.Research and practice in thrombosis and haemostasis · 2023Article
- Article
- Exploring the Villalta scale to capture postthrombotic syndrome using alternative approaches: A subanalysis of the ATTRACT trial.Research and practice in thrombosis and haemostasis · 2023Article
- S2k guidelines: diagnosis and treatment of varicose veins.Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2022Review
- Effects of physical activity as an adjunct treatment on healing outcomes and recurrence of venous leg ulcers: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022Article
- Pivotal Study Evaluating the Safety and Effectiveness of the Abre Venous Self-Expanding Stent System in Patients With Symptomatic Iliofemoral Venous Outflow Obstruction.Circulation. Cardiovascular interventions · 2022Article
- Reliability and validity of specific quality of life assessment questionnaires related to chronic venous insufficiency: a systematic review.Jornal vascular brasileiro · 2022Review
- International study to develop the WOUND-Q patient-reported outcome measure for all types of chronic wounds.International wound journal · 2021Article
- International mixed methods study protocol to develop a patient-reported outcome measure for all types of chronic wounds (the WOUND-Q).BMJ open · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundVEINES-QOL/Sym is a disease-specific quality of life instrument for use in venous diseases of the leg. Its relative scoring system precludes comparisons between studies. There were very few venous leg ulcer patients in the validation samples. We report a validation study for venous leg ulcers and develop a scoring system which enables comparison between studies.
methodsFour hundred fifty-one participants in the VenUS IV trial of the management of venous leg ulcers were asked to complete a VEINES-QOL questionnaire at recruitment, along with SF-12, pain, and other aspects of quality of life. VEINES-QOL was repeated after two weeks and after 4 months. Healing of ulcers was confirmed by blind assessment of digital photographs. Three scoring systems for VEINES-QOL were compared.
resultsNo floor or ceiling effects were observed for VEINES-QOL items, item-item correlations were weak to moderate, item-score correlations were moderate. Internal reliability was good. The VEINES-Sym subscale was confirmed by factor analysis. Test-retest reliability was satisfactory for the scale scores; individual items showed moderate to good agreement. Relationships with SF-12, pain, and the quality items confirmed construct validity. Participants whose ulcers had healed showed greater mean increase in scores than did those yet to heal, though they continued to report leg problems. An intrinsic scoring method appeared superior to the original relative method.
conclusionsVEINES-QOL was suitable for use in the study of venous leg ulcers. The intrinsic scoring method should be adopted, to facilitate comparisons between studies.
trial registrationVenUS IV is registered with the ISRCTN register, number ISRCTN49373072 .
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.