Evidence map›Paper›PMID 26260777›Full record

ArticleAnnals of epidemiology2015

A prospective analysis of diet quality and endometrial cancer among 84,415 postmenopausal women in the Women's Health Initiative.

Stephanie M George, Rachel Ballard, James M Shikany, Tracy E Crane, Marian L Neuhouser

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  5. Dietary interventions for adult cancer survivors.The Cochrane database of systematic reviews · 2019
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  15. Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephanie M GeorgeOffice of Disease Prevention, National Institutes of Health, Bethesda, MD. Electronic address: stephanie.george@nih.gov.
Rachel BallardOffice of Disease Prevention, National Institutes of Health, Bethesda, MD.
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham.
Tracy E CraneDepartment of Nutritional Sciences, University of Arizona, Tucson; University of Arizona Cancer Center, University of Arizona, Tucson; Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Funding

WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032115 · WH · UNIVERSITY OF ARIZONA · PI BASSFORD, TAMSEN E · 1993 to 2000
$196k
Intramural NIH HHS Z99 OD999999PHS HHS 24152PHS HHS 32100-2PHS HHS 32105-6PHS HHS 32108-9PHS HHS 32111-13PHS HHS 321115PHS HHS 32118-32119PHS HHS 32122PHS HHS 42107-26PHS HHS 42129-32PHS HHS 44221WHI NIH HHS N01 WH022110
6 · The paper itself

Abstract

purposeEndometrial cancer is the most commonly diagnosed gynecologic cancer, but no convincing dietary risk factors for this cancer have been identified. Among postmenopausal women, we examined how four key a priori diet quality indices--the Healthy Eating Index-2010, Alternative Healthy Eating Index-2010, alternate Mediterranean Diet, and Dietary Approaches to Stop Hypertension are related to the risk of endometrial cancer in the Women's Health Initiative Clinical Trials and Observational Study.

methodsOur prospective cohort study included 84,415 postmenopausal women with a uterus who completed a food frequency questionnaire at enrollment. Cox proportional hazards models were used to estimate multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for endometrial cancer associated with increasing quintiles of diet quality index scores.

resultsDuring 13.3 years of follow-up, 1392 endometrial cancer cases occurred. After adjustment for known risk factors, having better diet quality (Q5 vs. Q1) was not associated with the risk of endometrial cancer, as evidenced using Healthy Eating Index-2010 (HR: 1.11, 95% CI: 0.93-1.33), Alternative Healthy Eating Index-2010 (HR: 0.98, 95% CI: 0.82-1.17), alternate Mediterranean Diet (HR: 0.98, 95% CI: 0.82-1.17), or Dietary Approaches to Stop Hypertension (HR: 1.00, 95% CI: 0.84-1.19).

conclusionsDiet quality was not associated with endometrial cancer risk in this large cohort of postmenopausal women.

Indexed as

DietPostmenopauseAgedAge FactorsEndometrial NeoplasmsFeeding BehaviorFemaleHealth BehaviorHumansMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsSocioeconomic FactorsWomen's HealthDiet qualityEndometrial cancerProspective cohort study

Identifiers

PMID26260777
PMCPMC6980163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.