ReviewCancer research2015
Inferring the Origin of Metastases from Cancer Phylogenies.
Review in Cancer research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Identifying Robust Subclonal Structures through Tumor Progression Tree Alignment.bioRxiv : the preprint server for biology · 2026Article
- Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer.Nature communications · 2025Article
- Computationally reconstructing the evolution of cancer progression risk.bioRxiv : the preprint server for biology · 2024Article
- Single-cell methylation sequencing data reveal succinct metastatic migration histories and tumor progression models.Genome research · 2023Article
- Bone serves as a transfer station for secondary dissemination of breast cancer.Bone research · 2023Review
- Review
- Cellular barcoding to decipher clonal dynamics in disease.Science (New York, N.Y.) · 2022Review
- Article
- The Road to Dissemination: The Concept of Oligometastases and the Barriers for Widespread Disease.Cancers · 2022Review
- Mutational landscape of paired primary and synchronous metastatic lymph node in chemotherapy naive gallbladder cancer.Molecular biology reports · 2022Article
- CellPhy: accurate and fast probabilistic inference of single-cell phylogenies from scDNA-seq data.Genome biology · 2022Article
- Characterization of Clonal Evolution in Microsatellite Unstable Metastatic Cancers through Multiregional Tumor Sequencing.Molecular cancer research : MCR · 2021Article
- Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.Science (New York, N.Y.) · 2021Article
- Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data.Scientific reports · 2020Article
- Frontiers in Molecular Evolutionary Medicine.Journal of molecular evolution · 2020Review
- Quantitative evidence for early metastatic seeding in colorectal cancer.Nature genetics · 2019Article
- Predicting clone genotypes from tumor bulk sequencing of multiple samples.Bioinformatics (Oxford, England) · 2018Article
- The Spatiotemporal Evolution of Lymph Node Spread in Early Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Environmental Carcinogenesis and Transgenerational Transmission of Carcinogenic Risk: From Genetics to Epigenetics.International journal of environmental research and public health · 2018Article
- Neutral Theory and the Somatic Evolution of Cancer.Molecular biology and evolution · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Determining the evolutionary history of metastases is a key problem in cancer biology. Several recent studies have presented inferences regarding the origin of metastases based on phylogenies of cancer lineages. Many of these studies have concluded that the observed monophyly of metastatic subclones favored metastasis-to-metastasis spread ("a metastatic cascade" rather than parallel metastases from the primary tumor). In this article, we argue that identifying a monophyletic clade of metastatic subclones does not provide sufficient evidence to unequivocally establish a history of metastatic cascades. In the absence of a complete phylogeny of the subclones within the primary tumor, a scenario of parallel metastatic events from the primary tumor is an equally plausible interpretation. Future phylogenetic studies on the origin of metastases should obtain a complete phylogeny of subclones within the primary tumor. This complete phylogeny may be obtainable by ultra-deep sequencing and phasing of large sections or by targeted sequencing of many small, spatially heterogeneous sections, followed by phylogenetic reconstruction using well-established molecular evolutionary models. In addition to resolving the evolutionary history of metastases, a complete phylogeny of subclones within the primary tumor facilitates the identification of driver mutations by application of phylogeny-based tests of natural selection.
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Registered trials
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