ArticleScientific reports2015
Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- A phenotypically and functionally distinct human TScience translational medicine · 2017Trial
- Molecular mechanisms of lipid sensing in human cholecystokinin-secreting enteroendocrine cells.Molecular metabolism · 2026Article
- A Narrative Review on the Impact of Probiotic Supplementation on Muscle Development, Metabolic Regulation, and Fiber Traits Related to Meat Quality in Broiler Chickens.Microorganisms · 2025Review
- Orphan G protein-coupled receptors: the ongoing search for a home.Frontiers in pharmacology · 2024Review
- Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability.Nutrients · 2022Review
- Elucidation of the roles of brown and brite fat genes: GPR120 is a modulator of brown adipose tissue function.Experimental physiology · 2020Review
- Free Fatty Acid Receptors 2 and 3 as Microbial Metabolite Sensors to Shape Host Health: Pharmacophysiological View.Biomedicines · 2020Review
- The role of short-chain fatty acids in microbiota-gut-brain communication.Nature reviews. Gastroenterology & hepatology · 2019Review
- Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology.Comprehensive Physiology · 2018Review
- Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis.BMC research notes · 2018Article
- Dissecting the Physiology and Pathophysiology of Glucagon-Like Peptide-1.Frontiers in endocrinology · 2018Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
FFAR3 (GPR41) is a G-protein coupled receptor for which short-chain fatty acids serve as endogenous ligands. The receptor is found on gut enteroendocrine L-cells, pancreatic β-cells, and sympathetic neurons, and is implicated in obesity, diabetes, allergic airway disease, and altered immune function. In primates, FFAR3 is segmentally duplicated resulting in GPR42, a gene currently classified as a suspected pseudogene. In this study, we sequenced FFAR3 and GPR42 open reading frames from 56 individuals and found an unexpectedly high frequency of polymorphisms contributing to several complex haplotypes. We also identified a frequent (18.8%) structural variation that results in GPR42 copy number polymorphism. Finally, sequencing revealed that 50.6% of GPR42 haplotypes differed from FFAR3 by only a single non-synonymous substitution and that the GPR42 reference sequence matched only 4.4% of the alleles. Sequencing of cDNA from human sympathetic ganglia and colon revealed processed transcripts matching the GPR42 genotype. Expression of several GPR42 haplotypes in rat sympathetic neurons revealed diverse pharmacological phenotypes that differed in potency and efficacy. Our data suggest that GPR42 be reclassified as a functioning gene and that recognition of sequence and copy number polymorphism of the FFAR3/GPR42 complex be considered during genetic and pharmacological investigation of these receptors.
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