ArticleBrain pathology (Zurich, Switzerland)2016
Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample.
Article in Brain pathology (Zurich, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research.Frontiers in neurology · 2021Pooled it
- Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis.Neuropathology and applied neurobiology · 2018Pooled it
- Co-pathology in Alzheimer's disease and Lewy body disease and its association with neuropsychiatric symptoms.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Plasma TAR DNA-binding protein 43 (TDP-43) levels in a population-based cohort of older adults: The cardiovascular health study.Journal of Alzheimer's disease : JAD · 2025Article
- Evaluating the updated LATE-NC staging criteria using data from NACC.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Identifying and Diagnosing TDP-43 Neurodegenerative Diseases in Psychiatry.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Review
- LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry.Journal of neuropathology and experimental neurology · 2023Article
- TDP-43 Pathology in the Setting of Intermediate and High Alzheimer's Disease Neuropathologic Changes: A Preliminary Evaluation Across Ethnoracial Groups.Journal of Alzheimer's disease : JAD · 2023Article
- Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts.Acta neuropathologica · 2022Article
- Article
- Neuropathological lesions in the very old: results from a large Brazilian autopsy study.Brain pathology (Zurich, Switzerland) · 2019Article
- A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.Brain : a journal of neurology · 2019Article
- Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy.Neuroscience bulletin · 2019Article
- Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype.Acta neuropathologica · 2018Article
- TDP-43 pathology in anterior temporal pole cortex in aging and Alzheimer's disease.Acta neuropathologica communications · 2018Article
- The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology · 2018Review
- Detergent Insoluble Proteins and Inclusion Body-Like Structures Immunoreactive for PRKDC/DNA-PK/DNA-PKcs, FTL, NNT, and AIFM1 in the Amygdala of Cognitively Impaired Elderly Persons.Journal of neuropathology and experimental neurology · 2018Article
- TDP-43 pathology in Alzheimer's disease, dementia with Lewy bodies and ageing.Brain pathology (Zurich, Switzerland) · 2017Article
- Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study.PLoS medicine · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Transactive response DNA binding protein 43 (TDP-43) proteinopathy is the major hallmark of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. It is also present in a subset of Alzheimer's disease cases. Recently, few reports showed TDP-43 changes in cognitively normal elderly. In Caucasians, TDP-43 proteinopathy independently correlate with cognitive decline. However, it is challenging to establish direct links between cognitive and/or neuropsychiatric symptoms and protein inclusions in neurodegenerative diseases because individual cognitive reserves modify the threshold for clinical disease expression. Cognitive reserve is influenced by demographic, environmental and genetic factors. We investigated the relationships between demographic, clinical and neuropathological variables and TDP-43 proteinopathy in a large multiethnic sample of cognitively normal elderly. TDP-43 proteinopathy was identified in 10.5%, independently associated with older age (P = 0.03) and Asian ethnicity (P = 0.002). Asians showed a higher prevalence of TDP-43 proteinopathy than Caucasians, even after adjustment for sex, age, Braak stage and schooling (odds ratio = 3.50, confidence interval 1.41-8.69, P = 0.007). These findings suggested that Asian older adults may be protected from the clinical manifestation of brain TDP-43 proteinopathy. Future studies are needed to identify possible race-related protective factors against clinical expression of TDP-43 proteinopathies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.