ReviewNature reviews. Genetics2015
Genomes by design.
Review in Nature reviews. Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Enhanced eMAGE applied to identify genetic factors of nuclear hormone receptor dysfunction via combinatorial gene editing.Nature communications · 2024Article
- Cofitness network connectivity determines a fuzzy essential zone in open bacterial pangenome.mLife · 2024Article
- Exploring and mapping chemical space with molecular assembly trees.Science advances · 2021Article
- Understanding Metabolic Flux Behaviour in Whole-Cell Model Output.Frontiers in molecular biosciences · 2021Article
- Site-Selective and Rewritable Labeling of DNA through Enzymatic, Reversible, and Click Chemistries.ACS central science · 2020Article
- The case for biotech on Mars.Nature biotechnology · 2020Article
- Recent insights into the genotype-phenotype relationship from massively parallel genetic assays.Evolutionary applications · 2019Review
- The Role of Orthogonality in Genetic Code Expansion.Life (Basel, Switzerland) · 2019Article
- ZeBRα a universal, multi-fragment DNA-assembly-system with minimal hands-on time requirement.Scientific reports · 2019Article
- Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Upgrading aminoacyl-tRNA synthetases for genetic code expansion.Current opinion in chemical biology · 2018Review
- Beyond editing to writing large genomes.Nature reviews. Genetics · 2017Article
- Nucleosomal organization and DNA base composition patterns.Nucleus (Austin, Tex.) · 2017Review
- Millstone: software for multiplex microbial genome analysis and engineering.Genome biology · 2017Article
- Biofuel metabolic engineering with biosensors.Current opinion in chemical biology · 2016Review
- Nucleosomal signatures impose nucleosome positioning in coding and noncoding sequences in the genome.Genome research · 2016Article
- Vibrio natriegens as a fast-growing host for molecular biology.Nature methods · 2016Article
- Small Genetic Circuits and MicroRNAs: Big Players in Polymerase II Transcriptional Control in Plants.The Plant cell · 2016Review
- Recent advances and versatility of MAGE towards industrial applications.Systems and synthetic biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Next-generation DNA sequencing has revealed the complete genome sequences of numerous organisms, establishing a fundamental and growing understanding of genetic variation and phenotypic diversity. Engineering at the gene, network and whole-genome scale aims to introduce targeted genetic changes both to explore emergent phenotypes and to introduce new functionalities. Expansion of these approaches into massively parallel platforms establishes the ability to generate targeted genome modifications, elucidating causal links between genotype and phenotype, as well as the ability to design and reprogramme organisms. In this Review, we explore techniques and applications in genome engineering, outlining key advances and defining challenges.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.