ArticleMayo Clinic proceedings2015
Uric Acid: A Missing Link Between Hypertensive Pregnancy Disorders and Future Cardiovascular Disease?
Article in Mayo Clinic proceedings, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Decoding connections in the European population: serum uric acid, sex hormone-binding globulin, total testosterone, estradiol, and female infertility - advanced bidirectional and mediative Mendelian randomization.Frontiers in endocrinology · 2024Article
- Implications of serum uric acid for female infertility: results from the national health and nutrition examination survey, 2013-2020.BMC women's health · 2023Article
- Uric acid participating in female reproductive disorders: a review.Reproductive biology and endocrinology : RB&E · 2021Review
- Development and validation of a nomogram for the early prediction of preeclampsia in pregnant Chinese women.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- A Machine Learning-Based Prediction Model for Cardiovascular Risk in Women With Preeclampsia.Frontiers in cardiovascular medicine · 2021Article
- A risk factor-based predictive model for new-onset hypertension during pregnancy in Chinese Han women.BMC cardiovascular disorders · 2020Article
- Maternal Cardiovascular Risk Assessment 3-to-11 Years Postpartum in Relation to Previous Occurrence of Pregnancy-Related Complications.Journal of clinical medicine · 2019Article
- Uric acid and obesity-related phenotypes in postmenopausal women.Molecular and cellular biochemistry · 2018Article
- Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveTo determine whether women who had a hypertensive pregnancy disorder (HPD) have elevated uric acid concentrations decades after pregnancy as compared with women who had normotensive pregnancies. PATIENTS AND
methodsThe Genetic Epidemiology Network of Arteriopathy study measured uric acid concentrations in Hispanic (30%), non-Hispanic white (28%), and non-Hispanic black (42%) women (mean age, 60 ± 10 years). This cross-sectional study was conducted between July 1, 2000, and December 31, 2004. Hispanic participants were recruited from families with high rates of diabetes, whereas non-Hispanic participants were recruited from families with high rates of hypertension. This analysis compared uric acid concentrations in women with a history of normotensive (n = 1846) or hypertensive (n = 408) pregnancies by logistic regression.
resultsWomen who had an HPD had higher uric acid concentrations (median, 5.7 mg/dL vs 5.3 mg/dL; P < .001) and were more likely to have uric acid concentrations above 5.5 mg/dL (54.4% vs 42.4%; P = .001) than were women who had normotensive pregnancies. These differences persisted after adjusting for traditional cardiovascular risk factors, comorbidities, and other factors that affect uric acid concentrations. A family-based subgroup analysis comparing uric acid concentrations in women who had an HPD (n = 308) and their parous sisters who had normotensive pregnancies (n = 250) gave similar results (median uric acid concentrations, 5.7 mg/dL vs 5.2 mg/dL, P = 0.02; proportion of women with uric acid concentrations > 5.5 mg/dL, 54.0% vs 40.3%, P < .001).
conclusionDecades after pregnancy, women who had an HPD have higher uric acid concentrations. This effect does not appear to be explained by a familial predisposition to elevated uric acid concentrations.
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