Evidence map›Paper›PMID 26260123›Full record

ArticleNanoscale2015

Modeling nanoparticle wrapping or translocation in bilayer membranes.

Emily M Curtis, Amir H Bahrami, Thomas R Weikl, Carol K Hall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emily M CurtisDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Engineering Building I, 911 Partners Way, Raleigh, North Carolina 27695-7905, USA. hall@ncsu.edu.
Amir H Bahrami
Thomas R Weikl
Carol K Hall

Funding

Biotechnology Research Partnerships Renewal: Aggregation of Therapeutic ProteinsR01EB006006 · NIBIB · UNIVERSITY OF COLORADO · PI RANDOLPH, THEODORE W · 2006 to 2017
$7.2M
COMPUTER SIMULATION STUDIES OF PROTEIN AGGREGATIONR01GM056766 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HALL, CAROL K · 1999 to 2009
$1.4M
NIBIB NIH HHS EB006006NIBIB NIH HHS R01 EB006006NIGMS NIH HHS GM56766NIGMS NIH HHS R01 GM056766
6 · The paper itself

Abstract

The spontaneous wrapping of nanoparticles by membranes is of increasing interest as nanoparticles become more prevalent in consumer products and hence more likely to enter the human body. We introduce a simulations-based tool that can be used to visualize the molecular level interaction between nanoparticles and bilayer membranes. By combining LIME, an intermediate resolution, implicit solvent model for phospholipids, with discontinuous molecular dynamics (DMD), we are able to simulate the wrapping or embedding of nanoparticles by 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) bilayer membranes. Simulations of hydrophilic nanoparticles with diameters from 10 Å to 250 Å show that hydrophilic nanoparticles with diameters greater than 20 Å become wrapped while the nanoparticle with a diameter of 10 Å does not. Instead this smaller particle became embedded in the bilayer surface where it can interact with the hydrophilic head groups of the lipid molecules. We also investigate the interaction between a DPPC bilayer and hydrophobic nanoparticles with diameters 10 Å to 40 Å. These nanoparticles do not undergo the wrapping process; instead they directly penetrate the membrane and embed themselves within the inner hydrophobic core of the bilayers.

Indexed as

Molecular Dynamics Simulation1,2-DipalmitoylphosphatidylcholineHydrophobic and Hydrophilic InteractionsLipid BilayersNanoparticles1,2-DipalmitoylphosphatidylcholineLipid Bilayers

Identifiers

PMID26260123
PMCPMC4686374

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.