ArticleJournal of internal medicine2016
Functional and homeostatic defects of regulatory T cells in patients with coronary artery disease.
Article in Journal of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Aging-related immune phenotypes are associated with subclinical coronary atherosclerosis in a middle-aged population: a subcohort of the Swedish CArdioPulmonary bioImage Study.Immunity & ageing : I & A · 2026Article
- ER stress induced mitochondrial dysfunction drives Treg instability in coronary artery disease.EMBO molecular medicine · 2025Article
- Causal effects of circulating immune cells on coronary atherosclerosis: Evidence from Mendelian randomization.Medicine · 2025Article
- Immunological Regulation of Fibrosis During Heart Failure: It Takes Two to Tango.Biomolecules · 2025Review
- Inflammatory Biomarkers in Coronary Artery Disease: Insights From Mendelian Randomization and Transcriptomics.Journal of inflammation research · 2025Article
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- Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome.Frontiers in immunology · 2023Article
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- The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19.Life sciences · 2022Review
- Distinct Injury Responsive Regulatory T Cells Identified by Multi-Dimensional Phenotyping.Frontiers in immunology · 2022Article
- Review
- Oxidative stress response in regulatory and conventional T cells: a comparison between patients with chronic coronary syndrome and healthy subjects.Journal of translational medicine · 2021Article
- Trauma induces expansion and activation of a memory-like Treg population.Journal of leukocyte biology · 2021Article
- Heterogeneity of T Cells in Atherosclerosis Defined by Single-Cell RNA-Sequencing and Cytometry by Time of Flight.Arteriosclerosis, thrombosis, and vascular biology · 2021Review
- GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoEJournal of inflammation research · 2021Article
- Adaptive Immune Responses in Human Atherosclerosis.International journal of molecular sciences · 2020Review
- Tolerogenic vaccines for the treatment of cardiovascular diseases.EBioMedicine · 2020Review
- Regulatory T Cell Plasticity and Stability and Autoimmune Diseases.Clinical reviews in allergy & immunology · 2020Review
- An emerging role of regulatory T-cells in cardiovascular repair and regeneration.Theranostics · 2020Review
- The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations.European cardiology · 2019Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRegulatory T cells (Tregs) are considered atheroprotective, and low levels have been associated with the acute coronary syndrome (ACS), particularly non-ST elevation (NSTE)-ACS. However, the functional properties as well as homeostasis of Tregs are mainly unknown in coronary artery disease (CAD). Here, we investigated the composition and functional properties of naïve (n) and memory (m)Tregs in patients with NSTE-ACS and in patients 6-12 months post-ACS.
methodsBased on the expression of CD25, FOXP3, CD127, CD45RA, CD39 and CTLA-4, Treg subsets were defined by flow cytometry in whole blood or isolated CD4(+) T cells. The functional properties of nTregs and mTregs were examined in terms of proliferative capacity and modulation of cytokine secretion. To understand the potential consequences of Treg defects, we also investigated correlations with lipopolysaccharide (LPS)-induced cytokine secretion and ultrasound-defined carotid atherosclerosis.
resultsBoth NSTE-ACS and post-ACS patients exhibited reduced levels of nTregs (P < 0.001) compared with healthy control subjects, but without compensatory increases in mTregs. Both nTregs and mTregs from patients showed significantly lower replicative rates and impaired capacity to modulate T-cell proliferation and secretion of interferon-gamma and IL-10. The Treg defect was also associated with LPS-induced cytokine secretion and increased burden of carotid atherosclerosis.
conclusionOur results demonstrate a functional and homeostatic Treg defect in patients with NSTE-ACS and also in stabilized patients 6-12 months after ACS. Moreover, this defect was associated with a subclinical proinflammatory and atherogenic state. We believe that the failure to preserve Treg function and homeostasis reflects a need for immune-restoring strategies in CAD.
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