ArticleThe American journal of gastroenterology2016
Gluten Introduction, Breastfeeding, and Celiac Disease: Back to the Drawing Board.
Article in The American journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Low prevalence of celiac disease in French children, a nationwide study.Pediatric research · 2026Article
- Article
- Expression of MicroRNAs in Adults with Celiac Disease: A Narrative Review.International journal of molecular sciences · 2024Review
- Epidemiological, Endoscopic, Clinical, and Pathological Features of Patients with Celiac Diseases in Southern Littoral of Caspian Sea.Middle East journal of digestive diseases · 2023Article
- Review
- Genetic and environmental contributions to co-occurring physical health conditions in autism spectrum condition and attention-deficit/hyperactivity disorder.Molecular autism · 2023Article
- Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic.International journal of molecular sciences · 2022Review
- Celiac disease in children: A review of the literature.World journal of clinical pediatrics · 2021Review
- Review
- Extremely low prevalence of Celiac disease in Japan: Eternal silence or just the calm before the storm?JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- The Two Faces of Wheat.Frontiers in nutrition · 2020Review
- Elevated Levels of 1,25-Dihydroxyvitamin D in Plasma as a Missing Risk Factor for Celiac Disease.Clinical and experimental gastroenterology · 2020Article
- Celiac disease: should we care about microbes?American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Prevalence of markers of celiac disease in Colombian children with diabetes mellitus type 1.Colombia medica (Cali, Colombia) · 2018Article
- Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels.Advances in nutrition (Bethesda, Md.) · 2017Article
- [In time: celiac disease - some current aspects of epidemiology and research].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016Article
- Position Statement on Breastfeeding from the Italian Pediatric Societies.Italian journal of pediatrics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
This commentary by the leadership of the North American Society for the Study of Celiac Disease (NASSCD) concerns recent research findings regarding infant feeding practices. Celiac disease has increased markedly in recent decades, and seroprevalence studies indicate that this is a true rise, rather than one due to increased awareness and testing. Prior studies have suggested that infant feeding practices and timing of initial gluten exposure are central to the development of celiac disease. Two recent multicenter randomized trials tested strategies of early or delayed gluten introduction in infants, and neither strategy appeared to influence celiac disease risk. These studies also found that breastfeeding did not protect against the development of celiac disease. While disappointing, these results should spur the study of wider environmental risk factors beyond infant feeding, such as intrauterine and perinatal exposures as well as environmental influences later in life, including drug exposure, microbial infections, and the microbiome. Given that celiac disease can develop at any age, it is imperative to study these proposed triggers so as to elucidate the loss of tolerance to gluten and to develop future intervention strategies.
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Registered trials
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