ArticleScientific reports2015
Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 56 citations in OpenAlex.
- Evolving dynamics of H5Nx avian influenza in China revealed by long-term wild bird surveillance.Nature communications · 2026Article
- Global dynamics of avian influenza: a twenty-year analysis of highly pathogenic viruses linking the Caspian Basin, Eurasia and Africa sectors (2005-2025).Frontiers in cellular and infection microbiology · 2026Review
- Landscape changes elevate the risk of avian influenza virus diversification and emergence in the East Asian-Australasian Flyway.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pathogenicity, transmissibility, and receptor binding of a human-isolated influenza A (H10N5) virus.mBio · 2025Article
- Analysis of the surveillance results of avian influenza in the external environment of huzhou city from 2017 to 2023.PloS one · 2025Article
- Article
- Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication.Virologica Sinica · 2024Article
- Multidrug-resistant non-typhoidalFrontiers in microbiology · 2023Article
- Emergence, prevalence, and evolution of H5N8 avian influenza viruses in central China, 2020.Emerging microbes & infections · 2022Article
- Genetic and Pathogenic Characterization of Avian Influenza Virus in Migratory Birds between 2015 and 2019 in Central China.Microbiology spectrum · 2022Article
- Re-emergence of H5N8 highly pathogenic avian influenza virus in wild birds, China.Emerging microbes & infections · 2021Article
- KAv-1 is Better Suited to Chick Fibroblast Culture than DMEM or 199 Media.The journal of poultry science · 2021Article
- Novel reassortant 2.3.4.4B H5N6 highly pathogenic avian influenza viruses circulating among wild, domestic birds in Xinjiang, Northwest China.Journal of veterinary science · 2021Article
- Dominant subtype switch in avian influenza viruses during 2016-2019 in China.Nature communications · 2020Article
- Phylogeography of Highly Pathogenic H5 Avian Influenza Viruses in China.Virologica Sinica · 2020Article
- An assessment on potential risk pathways for the incursion of highly pathogenic avian influenza virus in backyard poultry farm in Bangladesh.Veterinary world · 2020Article
- Article
- A Review of Pathogen Transmission at the Backyard Chicken-Wild Bird Interface.Frontiers in veterinary science · 2020Review
- New evidence for the east-west spread of the highly pathogenic avian influenza H5N1 virus between Central Asian and east Asian-Australasian flyways in China.Emerging microbes & infections · 2019Article
- Diverse biological characteristics and varied virulence of H7N9 from Wave 5.Emerging microbes & infections · 2019Article
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Authors and funding
18 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 100 migratory birds, including whooper swans and pochards, were found dead in the Sanmenxia Reservoir Area of China during January 2015. The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). Genetic and phylogenetic analyses revealed that this Sanmenxia H5N1 virus was a novel reassortant, possessing a Clade 2.3.2.1c HA gene and a H9N2-derived PB2 gene. Sanmenxia Clade 2.3.2.1c-like H5N1 viruses possess the closest genetic identity to A/Alberta/01/2014 (H5N1), which recently caused a fatal respiratory infection in Canada with signs of meningoencephalitis, a highly unusual symptom with influenza infections in humans. Furthermore, this virus was shown to be highly pathogenic to both birds and mammals, and demonstrate tropism for the nervous system. Due to the geographical location of Sanmenxia, these novel H5N1 viruses also have the potential to be imported to other regions through the migration of wild birds, similar to the H5N1 outbreak amongst migratory birds in Qinghai Lake during 2005. Therefore, further investigation and monitoring is required to prevent this novel reassortant virus from becoming a new threat to public health.
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