ArticleUrologic oncology2015
Multiparametric magnetic resonance imaging-transrectal ultrasound fusion-assisted biopsy for the diagnosis of local recurrence after radical prostatectomy.
Article in Urologic oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Pattern of failure in prostate cancer previously treated with radical prostatectomy and post-operative radiotherapy: a secondary analysis of two prospective studies using novel molecular imaging techniques.Radiation oncology (London, England) · 2021Trial
- Trial
- Prospective, Multisite, International Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Trial
- Reproducibility of Multiparametric Magnetic Resonance Imaging and Fusion Guided Prostate Biopsy: Multi-Institutional External Validation by a Propensity Score Matched Cohort.The Journal of urology · 2016Trial
- Diagnostic Value of Micro-Ultrasound in Identifying Local Recurrence After Radical Prostatectomy.The Prostate · 2026Article
- Dynamic Contrast-Enhanced Study in the mpMRI of the Prostate-Unnecessary or Underutilised? A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
- Head-to-head comparison of pressures during full cystometry, with clinical as well as in-depth signal-analysis, of air-filled catheters versus the ICS-standard water-filled catheters.Neurourology and urodynamics · 2021Article
- Detecting recurrent prostate Cancer using multiparametric MRI, influence of PSA and Gleason grade.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021Article
- Radiation Therapy After Radical Prostatectomy: What Has Changed Over Time?Frontiers in surgery · 2021Review
- Article
- Patient Demographics and Referral Patterns for [F-18]Fluciclovine-PET Imaging at a Tertiary Academic Medical Center.Journal of the American College of Radiology : JACR · 2019Article
- Cost consideration in utilization of multiparametric magnetic resonance imaging in prostate cancer.Translational andrology and urology · 2017Review
- MR/US Fusion Technology: What Makes It Tick?Current urology reports · 2017Review
- Molecular imaging and fusion targeted biopsy of the prostate.Clinical and translational imaging · 2017Article
- Tumor contact with prostate capsule on magnetic resonance imaging: A potential biomarker for staging and prognosis.Urologic oncology · 2017Article
- Risk stratification of prostate cancer: integrating multiparametric MRI, nomograms and biomarkers.Future oncology (London, England) · 2016Review
- Localizing sites of disease in patients with rising serum prostate-specific antigen up to 1ng/ml following prostatectomy: How much information can conventional imaging provide?Urologic oncology · 2016Article
- Evaluation of Prostate Cancer with PET/MRI.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2016Review
- Magnetic resonance-ultrasound fusion prostate biopsy in the diagnosis of prostate cancer.Urologic oncology · 2016Review
- DCE MRI of prostate cancer.Abdominal radiology (New York) · 2016Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveApproximately 15% of patients who undergo radical prostatectomy (RP) for prostate cancer develop local recurrence, which is heralded by a rise in serum prostate-specific antigen (PSA) levels. Early detection and treatment of recurrence improves the outcome of salvage treatment. We investigated the ability of multiparametric magnetic resonance imaging (mpMRI)-transrectal ultrasound (TRUS) fusion-guided biopsy (FGB) combined with "cognitive biopsy" to confirm local recurrence of prostate cancer after RP. MATERIALS AND
methodsIn this retrospective study conducted between January 2010 and December 2014, patients with rising PSA levels after RP who had no known evidence of distant metastases underwent mpMRI including T2-weighted (T2W) imaging, diffusion-weighted imaging, dynamic contrast-enhanced (DCE) MRI at 3 Tesla, and subsequent MRI-ultrasound fusion biopsy with cognitive assistance. The detection rate of locally recurrent disease was determined.
resultsA total of 10 patients (mean age = 67y, mean PSA level = 3.44ng/ml) met the inclusion criteria. Of the 10 patients, all had positive findings suspicious for local recurrence on mpMRI per entrance criterion. The most important features on mpMRI were early enhancement on DCE MR images and hypointensity on T2W images. The average lesion diameter on mpMRI was 1.12cm (range: 0.40-2.20cm). All suspicious lesions (16/16, 100%) were positive on T2W MR images, 14 (89%) showed positive features on apparent diffusion coefficient maps of diffusion-weighted images, and 16 (100%) were positive on DCE MR images. MRI-TRUS FGBs were positive in 10/16 lesions (62.5%) and 8/10 (80%) patients.
conclusionMRI-TRUS FGB with cognitive assistance is able to detect and diagnose locally recurrent lesions after RP, even at low PSA levels. This may facilitate early detection of recurrent disease and improve salvage treatment outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.