Evidence map›Paper›PMID 26259088›Full record

ReviewAlcohol research : current reviews2015

Utilization of Magnetic Resonance Imaging in Research Involving Animal Models of Fetal Alcohol Spectrum Disorders.

Xiaojie Wang, Christopher D Kroenke

Open access · greenAbstract readReview
In one paragraph

Review in Alcohol research : current reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption.Alcoholism, clinical and experimental research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaojie WangDivision of Neuroscience, Oregon National Primate Center, Oregon Health and Science University, Portland, Oregon.
Christopher D KroenkeDivision of Neuroscience, Oregon National Primate Center; Advanced Imaging Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon.
Oregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Characterizing the FASD cerebral cortex in utero with DTIR01AA021981 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KROENKE, CHRISTOPHER D · 2013 to 2017
$2.3M
Tim Upgrade for Nonhuman-Primate-Dedicated Magnetom TrioS10RR027238 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KROENKE, CHRISTOPHER D · 2010 to 2010
$500k
NCRR NIH HHS S10 RR027238NIAAA NIH HHS R01 AA021981NIH HHS P51 OD011092
6 · The paper itself

Abstract

It is well recognized that fetal alcohol exposure can profoundly damage the developing brain. The term fetal alcohol spectrum disorder (FASD) describes the range of deficits that result from prenatal alcohol exposure. Over the past two decades, researchers have used magnetic resonance imaging (MRI) as a noninvasive technique to characterize anatomical, physiological, and metabolic changes in the human brain that are part of FASD. As using animal models can circumvent many of the complications inherent to human studies, researchers have established and explored a number of models involving a range of species. Using MRI-based modalities, the FASD animal models have demonstrated decreased brain volume and abnormal brain shape, disrupted cellular morphology differentiation, altered neurochemistry, and blood perfusion. These animal studies have facilitated characterization of the direct effects of ethanol; in many cases identifying specific sequelae related to the timing and dose of exposure. Further, as a result of the ability to perform traditional (such as histological) analyses on animal brains following neuroimaging experiments, this work leads to improvements in the accuracy of our interpretations of neuroimaging findings in human studies.

Indexed as

Disease Models, AnimalAnimalsFetal Alcohol Spectrum DisordersHumansMagnetic Resonance Imaging

Identifiers

PMID26259088
PMCPMC4476603
OpenAlexW1131346993

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.