ArticleNature communications2015
Genome-wide analysis of the genetic regulation of gene expression in human neutrophils.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Early clearance of Chikungunya virus in children is associated with a strong innate immune response.Scientific reports · 2016Pooled it
- Multi‑omics reveal neutrophil heterogeneity in sepsis (Review).International journal of molecular medicine · 2025Review
- Single cell transcriptomics in blood of patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2025Article
- Identification of SNPs and Candidate Genes Associated with Monocyte/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio in Duroc × Erhualian FInternational journal of molecular sciences · 2024Article
- Deep resequencing identifies candidate functional genes in leprosy GWAS loci.PLoS neglected tropical diseases · 2021Article
- Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.Nature genetics · 2021Article
- An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population.Human molecular genetics · 2021Article
- Article
- Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations.Genes · 2020Article
- Article
- Genetics of leprosy: today and beyond.Human genetics · 2020Review
- Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome.Genomics, proteomics & bioinformatics · 2019Article
- Heterogeneity of neutrophils.Nature reviews. Immunology · 2019Review
- Identification of Potential Transcriptional Biomarkers Differently Expressed in BothBioMed research international · 2019Article
- Context-specific effects of genetic variants associated with autoimmune disease.Human molecular genetics · 2017Review
- Identification of context-dependent expression quantitative trait loci in whole blood.Nature genetics · 2017Article
- DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.Clinical epigenetics · 2017Article
- Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity.Genes and immunity · 2016Article
- Genetic analysis of innate immunity in Behcet's disease identifies an association with IL-37 and IL-18RAP.Scientific reports · 2016Article
- Characterization of candidate genes in inflammatory bowel disease-associated risk loci.JCI insight · 2016Article
Corrections and comments
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Authors and funding
27 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are an abundant immune cell type involved in both antimicrobial defence and autoimmunity. The regulation of their gene expression, however, is still largely unknown. Here we report an eQTL study on isolated neutrophils from 114 healthy individuals of Chinese ethnicity, identifying 21,210 eQTLs on 832 unique genes. Unsupervised clustering analysis of these eQTLs confirms their role in inflammatory responses and immunological diseases but also indicates strong involvement in dermatological pathologies. One of the strongest eQTL identified (rs2058660) is also the tagSNP of a linkage block reported to affect leprosy and Crohn's disease in opposite directions. In a functional study, we can link the C allele with low expression of the β-chain of IL18-receptor (IL18RAP). In neutrophils, this results in a reduced responsiveness to IL-18, detected both on the RNA and protein level. Thus, the polymorphic regulation of human neutrophils can impact beneficial as well as pathological inflammatory responses.
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