ArticleAmerican journal of respiratory and critical care medicine2015
Endotoxin Exposure: Predictors and Prevalence of Associated Asthma Outcomes in the United States.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.Thorax · 2021Pooled it
- Association of indoor microbial aerosols with respiratory symptoms among under-five children: a systematic review and meta-analysis.Environmental health : a global access science source · 2021Pooled it
- Trial
- Gamma tocopherol-enriched supplement reduces sputum eosinophilia and endotoxin-induced sputum neutrophilia in volunteers with asthma.The Journal of allergy and clinical immunology · 2018Trial
- Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children.The Journal of allergy and clinical immunology · 2018Trial
- The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned.Contemporary clinical trials · 2017Trial
- Influence of exposure to coarse, fine and ultrafine urban particulate matter and their biological constituents on neural biomarkers in a randomized controlled crossover study.Environment international · 2017Trial
- A novel ambient air sampler for detection of allergens and endotoxin.The journal of allergy and clinical immunology. Global · 2026Article
- Indoor allergens and endotoxins in relation to cockroach infestations in low-income urban homes.The journal of allergy and clinical immunology. Global · 2026Article
- Indoor allergen exposure in relation to sleep health among US adults.The journal of allergy and clinical immunology. Global · 2025Article
- Pets and related allergens modify the association between early life DEHP exposure and respiratory outcomes in children.Environmental research · 2025Article
- Comparative analysis of ambient, in-home, and personal exposures reveals associations between breathing zone pollutant levels and asthma exacerbations in high-risk children.Respiratory research · 2025Article
- Joint association of indoor allergens, endotoxins, heavy metals, and parabens with allergy-related outcomes in U. S. adults.Frontiers in public health · 2025Article
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- An algorithm for quantitatively estimating occupational endotoxin exposure in the biomarkers of exposure and effect in agriculture study: II. Application to the study population.American journal of industrial medicine · 2023Article
- Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.Journal of translational medicine · 2023Article
- Scratching the Surface Takes a Toll: Immune Recognition of Viral Proteins by Surface Toll-like Receptors.Viruses · 2022Review
- The influence of urban exposures and residence on childhood asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
- Asthma and obesity: endotoxin another insult to add to injury?Clinical science (London, England : 1979) · 2021Review
- Effects of early-life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study.Clinical and translational allergy · 2021Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleInhaled endotoxin induces airway inflammation and is an established risk factor for asthma. The 2005-2006 National Health and Nutrition Examination Survey included measures of endotoxin and allergens in homes as well as specific IgE to inhalant allergens.
objectivesTo understand the relationships between endotoxin exposure, asthma outcomes, and sensitization status for 15 aeroallergens in a nationally representative sample.
methodsParticipants were administered questionnaires in their homes. Reservoir dust was vacuum sampled to generate composite bedding and bedroom floor samples. We analyzed 7,450 National Health and Nutrition Examination Survey dust and quality assurance samples for their endotoxin content using extreme quality assurance measures. Data for 6,963 subjects were available, making this the largest study of endotoxin exposure to date. Log-transformed endotoxin concentrations were analyzed using logistic models and forward stepwise linear regression. Analyses were weighted to provide national prevalence estimates and unbiased variances. MEASUREMENTS AND MAIN
resultsEndotoxin exposure was significantly associated with wheeze in the past 12 months, wheeze during exercise, doctor and/or emergency room visits for wheeze, and use of prescription medications for wheeze. Models adjusted for age, sex, race and/or ethnicity, and poverty-to-income ratio and stratified by allergy status showed that these relationships were not dependent upon sensitization status but were worsened among those living in poverty. Significant predictors of higher endotoxin exposures were lower family income; Hispanic ethnicity; participant age; dog(s), cat(s), cockroaches, and/or smoker(s) in the home; and carpeted floors.
conclusionsIn this U.S. nationwide representative sample, higher endotoxin exposure was significantly associated with measures of wheeze, with no observed protective effect regardless of sensitization status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.