ArticleAdvances in skin & wound care2015
Epidermal micrografts produced via an automated and minimally invasive tool form at the dermal/epidermal junction and contain proliferative cells that secrete wound healing growth factors.
Article in Advances in skin & wound care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Systematic review and meta-analysis of the use of micrografting technology in humans.The Journal of international medical research · 2025Pooled it
- Trial
- An Automated and Minimally Invasive Tool for Generating Autologous Viable Epidermal Micrografts.Advances in skin & wound care · 2016Trial
- Efficiency of Epidermal Grafts in Chronic Wounds: A Retrospective Observational Study.Health science reports · 2025Article
- Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in anFrontiers in medicine · 2025Article
- FastSkinJournal of clinical medicine · 2023Article
- Evaluating the Application Potential of a RecombinantMolecules (Basel, Switzerland) · 2023Article
- Self-assembly of tessellated tissue sheets by expansion and collision.Nature communications · 2022Article
- The use of autologous epidermal grafts for diabetic foot ulcer emergencies: A clinical study.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Skin grafting treatment of adolescent lower limb avulsion injury.Frontiers in surgery · 2022Review
- The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review.Bioengineering (Basel, Switzerland) · 2021Review
- Immune tolerance of allogeneic haematopoietic cell transplantation supports donor epidermal grafting of recessive dystrophic epidermolysis bullosa chronic wounds.The British journal of dermatology · 2021Article
- Comparative study on the donor site aesthetic outcome between epidermal graft and split-thickness skin graft.International wound journal · 2019Article
- Use of Cellutome for the healing of venous or mixed ulcers.International wound journal · 2018Article
- Use of epidermal skin grafts in chronic wounds: a case series.International wound journal · 2017Article
- Treatment of standardised wounds with pure epidermal micrografts generated with an automated device.International wound journal · 2017Article
- Epidermal grafting for wound healing: a review on the harvesting systems, the ultrastructure of the graft and the mechanism of wound healing.International wound journal · 2017Review
- Article
- Article
- A Case Series of Complex Recalcitrant Wounds Treated with Epidermal Grafts Harvested from an Automated Device.Cureus · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this scientific study was to assess epidermal micrografts for formation at the dermal-epidermal (DE) junction, cellular outgrowth, and growth factor secretion. Epidermal harvesting is an autologous option that removes only the superficial epidermal layer of the skin, considerably limiting donor site damage and scarring. Use of epidermal grafting in wound healing has been limited because of tedious, time-consuming, and inconsistent methodologies. Recently, a simplified, automated epidermal harvesting tool (CelluTome Epidermal Harvesting System; Kinetic Concepts Inc, San Antonio, Texas) that applies heat and suction concurrently to produce epidermal micrografts has become commercially available. The new technique of epidermal harvesting was shown to create viable micrografts with minimal patient discomfort and no donor-site scarring.
designThis study was a prospective institutional review board-approved healthy human study.
settingThis study was conducted at the multispecialty research facility, Clinical Trials of Texas, Inc, in San Antonio, Texas. PATIENTS: The participants were 15 healthy human volunteers.
resultsEpidermal micrografts formed at the DE junction, and migratory basal layer keratinocytes and melanocytes were proliferative in culture. Basement membrane-specific collagen type IV was also found to be present in the grafts, suggesting that the combination of heat and vacuum might cause partial delamination of the basement membrane. Viable basal cells actively secreted key growth factors important for modulating wound healing responses, including vascular endothelial growth factor, hepatocyte growth factor, granulocyte colony-stimulating factor, platelet-derived growth factor, and transforming growth factor α.
conclusionsHarvested epidermal micrografts retained their original keratinocyte structure, which is critical for potential re-epithelialization and repigmentation of a wound environment.
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Registered trials
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