Observational studyAnnals of surgery2015
Defining long-term outcomes with living donor liver transplantation in North America.
Observational study in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adult-to-Adult Living Donor Liver Transplantation Cohort Study
A2ALL: Adult-to-Adult Living Transplant Cohort Study
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 174 citations in OpenAlex.
- A qualitative systematic review of anonymous/unspecified living kidney and liver donors' perspectives.PloS one · 2022Pooled it
- Meta-analysis and meta-regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Pooled it
- The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline.Transplantation · 2017Guideline
- Liver transplant for paediatric acute liver failure: insights from a newly established paediatric liver transplant program in a developing country.BMC pediatrics · 2026Article
- Effects of the bile duct bifurcation angle and position of the living donor on biliary complications in recipients after living donor liver transplantation.BMC surgery · 2026Article
- Fulminant hepatitis A in a robust adult: a case report of acute liver failure requiring urgent living donor liver transplantation.AME case reports · 2026Article
- Pre-operative assessment of living liver donors' liver anatomy and volumes.Updates in surgery · 2025Review
- Article
- Living Donor Liver Transplantation Versus Deceased Donor Liver Transplantation for Hepatocellular Carcinoma and HCV Patients: An Initial Umbrella Review.Journal of clinical medicine · 2025Review
- Hepatocellular Carcinoma and the Role of Liver Transplantation: An Update and Review.Journal of clinical and translational hepatology · 2025Review
- The Survival Rate of Living-Donor Liver Transplantation Between Same-Sex and Opposite-Sex Recipients.Diagnostics (Basel, Switzerland) · 2025Article
- Living Donor Liver Transplantation with Small Left Lobe Grafts: Prospective Validation of Utility of Splenectomy in Selected Recipients.Annals of transplantation · 2025Article
- The application of real-time indocyanine green fluorescence cholangiography in laparoscopic living donor left lateral sectionectomy.Hepatobiliary surgery and nutrition · 2024Article
- Early Graft Failure After Living-Donor Liver Transplant.Digestive diseases and sciences · 2024Article
- Transplant oncology - Current indications and strategies to advance the field.JHEP reports : innovation in hepatology · 2024Review
- Peripheral Injection of hUC-MSCs in the Treatment of Acute Liver Failure: A Pre-Clinical Cohort Study in Rhesus Monkeys.Stem cells international · 2024Article
- Review
- Current Status of Living Donor Liver Transplantation: Impact, Advantages, and Challenges.Current gastroenterology reports · 2023Review
- Comparing High- and Low-Model for End-Stage Liver Disease Living-Donor Liver Transplantation to Determine Clinical Efficacy: A Systematic Review and Meta-Analysis (CHALICE Study).Journal of clinical medicine · 2023Review
- Living-Donor Liver Transplant and Improved Post-Transplant Survival in Patients with Primary Sclerosing Cholangitis.Journal of clinical medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 12 institutions in 2 countries.
Funding
Abstract
objectivesTo compare long-term survival of living donor liver transplant (LDLT) at experienced transplant centers with outcomes of deceased donor liver transplant and identify key variables impacting patient and graft survival.
backgroundThe Adult-to-Adult Living Donor Liver Transplantation Cohort Study is a prospective multicenter National Institutes of Health study comparing outcomes of LDLT and deceased donor liver transplant and associated risks.
methodsMortality and graft failure for 1427 liver recipients (963 LDLT) enrolled in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study who received transplant between January 1, 1998, and January 31, 2014, at 12 North American centers with median follow-up 6.7 years were analyzed using Kaplan-Meier and multivariable Cox models.
resultsSurvival probability at 10 years was 70% for LDLT and 64% for deceased donor liver transplant. Unadjusted survival was higher with LDLT (hazard ratio = 0.76, P = 0.02) but attenuated after adjustment (hazard ratio = 0.98, P = 0.90) as LDLT recipients had lower mean model for end-stage liver disease (15.5 vs 20.4) and fewer received transplant from intensive care unit, were inpatient, on dialysis, were ventilated, or with ascites. Posttransplant intensive care unit days were less for LDLT recipients. For all recipients, female sex and primary sclerosing cholangitis were associated with improved survival, whereas dialysis and older recipient/donor age were associated with worse survival. Higher model for end-stage liver disease score was associated with increased graft failure. Era of transplantation and type of donated lobe did not impact survival in LDLT.
conclusionsLDLT provides significant long-term transplant benefit, resulting in transplantation at a lower model for end-stage liver disease score, decreased death on waitlist, and excellent posttransplant outcomes. Recipient diagnosis, disease severity, renal failure, and ages of recipient and donor should be considered in decision making regarding timing of transplant and donor options.Clinical Trials ID: NCT00096733.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.