ReviewJournal of immunology research2015
Sepsis: From Pathophysiology to Individualized Patient Care.
Review in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): a Prospective, Randomized, Multicenter Clinical Trial
Innovative Solutions to Organ-substituting Technologies in the Treatment of Heart and Pulmonary Failure
Development of Innovative Technologies for the Treatment of Pulmonary and Heart Failure to Prolong Human's Life
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- The impact of RAGE inhibition in animal models of bacterial sepsis: a systematic review and meta-analysis.The Journal of international medical research · 2018Pooled it
- Sepsis in Dogs and Cats-Consensus Definition and Clinical Criteria.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)Pooled it
- A dataset of paired blood mRNA and microRNA sequencing across acute septic shock and recovery.Scientific data · 2026Article
- Choline in immunity: a key regulator of immune cell activation and function.Frontiers in immunology · 2025Review
- Estimation of optimal treatment regimes with electronic medical record data using the residual life value estimator.Biostatistics (Oxford, England) · 2024Article
- Platelet Indices in Patients With Gram-Negative and Gram-Positive Sepsis: A Retrospective Cross-Sectional Study.Cureus · 2024Article
- Clinical phenotypes of sepsis: a narrative review.Journal of thoracic disease · 2024Review
- Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock: An Indian perspective.World journal of critical care medicine · 2024Article
- Tau and Aβ42 in lavage fluid of pneumonia patients are associated with end-organ dysfunction: A prospective exploratory study.PloS one · 2024Observational
- Measurement of Urinary Gc-Globulin by a Fluorescence ELISA Technique: Method Validation and Clinical Evaluation in Septic Patients-A Pilot Study.Molecules (Basel, Switzerland) · 2023Article
- DYNAMIC PREDICTION OF RESIDUAL LIFE WITH LONGITUDINAL COVARIATES USING LONG SHORT-TERM MEMORY NETWORKS.The annals of applied statistics · 2023Article
- Extracorporeal blood purification strategies in sepsis and septic shock: An insight into recent advancements.World journal of critical care medicine · 2023Review
- Distinct patterns of serum and urine macrophage migration inhibitory factor kinetics predict death in sepsis: a prospective, observational clinical study.Scientific reports · 2023Observational
- Phenotyping cardiogenic shock that showed different clinical outcomes and responses to vasopressor use: a latent profile analysis from MIMIC-IV database.Frontiers in medicine · 2023Article
- Septic Shock: Phenotypes and Outcomes.Advances in therapy · 2022Article
- COVID-19 and Long-Term Outcomes: Lessons from Other Critical Care Illnesses and Potential Mechanisms.American journal of respiratory cell and molecular biology · 2022Article
- A prospective observational cohort study to identify inflammatory biomarkers for the diagnosis and prognosis of patients with sepsis.Journal of intensive care · 2022Article
- Article
- A Porcine Sepsis Model With Numerical Scoring for Early Prediction of Severity.Frontiers in medicine · 2022Article
- High Mobility Group Proteins in Sepsis.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis has become a major health economic issue, with more patients dying in hospitals due to sepsis related complications compared to breast and colorectal cancer together. Despite extensive research in order to improve outcome in sepsis over the last few decades, results of large multicenter studies were by-and-large very disappointing. This fiasco can be explained by several factors, but one of the most important reasons is the uncertain definition of sepsis resulting in very heterogeneous patient populations, and the lack of understanding of pathophysiology, which is mainly based on the imbalance in the host-immune response. However, this heroic research work has not been in vain. Putting the results of positive and negative studies into context, we can now approach sepsis in a different concept, which may lead us to new perspectives in diagnostics and treatment. While decision making based on conventional sepsis definitions can inevitably lead to false judgment due to the heterogeneity of patients, new concepts based on currently gained knowledge in immunology may help to tailor assessment and treatment of these patients to their actual needs. Summarizing where we stand at present and what the future may hold are the purpose of this review.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.