ArticleFrontiers in bioengineering and biotechnology2015
Automatic Evaluation of Speech Rhythm Instability and Acceleration in Dysarthrias Associated with Basal Ganglia Dysfunction.
Article in Frontiers in bioengineering and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- Artificial Intelligence in Biomedicine: A Systematic Review from Nanomedicine to Neurology and Hepatology.Pharmaceutics · 2025Review
- Speech Markers of Parkinson's Disease: Phonological Features and Acoustic Measures.Brain sciences · 2025Article
- Speech Differences between Multiple System Atrophy and Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Spectro-Image Analysis with Vision Graph Neural Networks and Contrastive Learning for Parkinson's Disease Detection.Journal of imaging · 2025Article
- Speech subtypes are associated with worsened tremor and axial symptoms in Parkinson's disease patients.Clinical parkinsonism & related disorders · 2025Article
- AI-driven precision diagnosis and treatment in Parkinson's disease: a comprehensive review and experimental analysis.Frontiers in aging neuroscience · 2025Article
- Speech's syllabic rhythm and articulatory features produced under different auditory feedback conditions identify Parkinsonism.Scientific reports · 2024Article
- Automatic speech-based assessment to discriminate Parkinson's disease from essential tremor with a cross-language approach.NPJ digital medicine · 2024Article
- A neurocomputational view of the effects of Parkinson's disease on speech production.Frontiers in human neuroscience · 2024Article
- Analyzing changes in parkinsonian speech over time: a diachronic experimental phonetics study.Frontiers in aging neuroscience · 2024Article
- Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Cognitive profile of patients with and without speech impairment in Parkinson's disease.Dementia & neuropsychologia · 2023Article
- Deep Clinical Phenotyping of Parkinson's Disease: Towards a New Era of Research and Clinical Care.Phenomics (Cham, Switzerland) · 2022Review
- The language profile in multiple system atrophy: an exploratory study.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Evaluating a Speech-Specific and a Computerized Step-Training-Specific Rhythmic Intervention in Parkinson's Disease: A Cross-Over, Multi-Arms Parallel Study.Frontiers in rehabilitation sciences · 2021Article
- Controlling Clinical States Governed by Different Temporal Dynamics With Closed-Loop Deep Brain Stimulation: A Principled Framework.Frontiers in neuroscience · 2021Article
- Understanding speech and swallowing difficulties in individuals with Huntington disease: Validation of the HDQLIFE Speech Difficulties and Swallowing Difficulties Item Banks.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Speech-Language Pathology Evaluation and Management of Hyperkinetic Disorders Affecting Speech and Swallowing Function.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Towards the identification of Idiopathic Parkinson's Disease from the speech. New articulatory kinetic biomarkers.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Speech rhythm abnormalities are commonly present in patients with different neurodegenerative disorders. These alterations are hypothesized to be a consequence of disruption to the basal ganglia circuitry involving dysfunction of motor planning, programing, and execution, which can be detected by a syllable repetition paradigm. Therefore, the aim of the present study was to design a robust signal processing technique that allows the automatic detection of spectrally distinctive nuclei of syllable vocalizations and to determine speech features that represent rhythm instability (RI) and rhythm acceleration (RA). A further aim was to elucidate specific patterns of dysrhythmia across various neurodegenerative disorders that share disruption of basal ganglia function. Speech samples based on repetition of the syllable /pa/ at a self-determined steady pace were acquired from 109 subjects, including 22 with Parkinson's disease (PD), 11 progressive supranuclear palsy (PSP), 9 multiple system atrophy (MSA), 24 ephedrone-induced parkinsonism (EP), 20 Huntington's disease (HD), and 23 healthy controls. Subsequently, an algorithm for the automatic detection of syllables as well as features representing RI and RA were designed. The proposed detection algorithm was able to correctly identify syllables and remove erroneous detections due to excessive inspiration and non-speech sounds with a very high accuracy of 99.6%. Instability of vocal pace performance was observed in PSP, MSA, EP, and HD groups. Significantly increased pace acceleration was observed only in the PD group. Although not significant, a tendency for pace acceleration was observed also in the PSP and MSA groups. Our findings underline the crucial role of the basal ganglia in the execution and maintenance of automatic speech motor sequences. We envisage the current approach to become the first step toward the development of acoustic technologies allowing automated assessment of rhythm in dysarthrias.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.