ArticleAdipocyte
Wt1, the mesothelium and the origins and heterogeneity of visceral fat progenitors.
Article in Adipocyte. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Integrative analysis of gene expression and histone modifications for DES, DSP, GJA1 and SMOC2 in adipose tissue reveals potential relationship to cardiometabolic health.Molecular medicine (Cambridge, Mass.) · 2025Article
- WT1 in Adipose Tissue: From Development to Adult Physiology.Frontiers in cell and developmental biology · 2022Review
- Identifying Key Genes and Functionally Enriched Pathways of Diverse Adipose Tissue Types in Cattle.Frontiers in genetics · 2022Article
- Hematopoietic Stem Cell-Derived Adipocytes Modulate Adipose Tissue Cellularity, Leptin Production and Insulin Responsiveness in Female Mice.Frontiers in endocrinology · 2022Article
- Article
- Cafeteria diet induces global andAdipocyte · 2021Article
- Cholesterol is required for transcriptional repression by BASP1.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Adipose Tissue: Understanding the Heterogeneity of Stem Cells for Regenerative Medicine.Biomolecules · 2021Review
- Crohn's Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat.International journal of molecular sciences · 2021Article
- A Small Fraction of Progenitors Differentiate Into Mature Adipocytes by Escaping the Constraints on the Cell Structure.Frontiers in cell and developmental biology · 2021Article
- Transcriptomic Changes of Murine Visceral Fat Exposed to Intermittent Hypoxia at Single Cell Resolution.International journal of molecular sciences · 2020Article
- Single cell approaches to address adipose tissue stromal cell heterogeneity.The Biochemical journal · 2020Review
- Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules.Experimental & molecular medicine · 2017Review
- Article
- Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals.Clinical epigenetics · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One major gap in adipocyte biology has been a lack of understanding of the developmental origins of the different visceral white adipose tissue (WAT) depots and subcutaneous WAT. In a recent study we showed that most visceral WAT but no subcutaneous WAT arises from cells expressing the Wilms' tumor 1 (Wt1) gene late in mouse gestation.(1) Wt1 continues to be expressed in visceral WAT progenitors into adult life. We also showed that visceral WAT is lined by a mesothelium and provided evidence that this structure is the source of adipocytes. Our study also adds to the growing body of evidence that there is heterogeneity in the visceral progenitors, such that there are Wt1-expressing and non-expressing subsets, the relative proportions of which vary between depots. This raises the enticing prospect that the adipocytes arising from these progenitor subsets may have different properties and our preliminary data support this notion. Finally, evidence from our study and one from Spiegelman's group(2) suggests that Wt1 is not just a marker but regulates visceral WAT identity and the progenitor population. We discuss the implications of this work and some of the questions and future directions that arise from it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.