Evidence map›Paper›PMID 26257930›Full record

ReviewJournal of advanced research2015

Brain stem adenosine receptors modulate centrally mediated hypotensive responses in conscious rats: A review.

Noha N Nassar, Abdel A Abdel-Rahman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Effect of Endogenous Adenosine on Neuronal Activity in Rats: An FDG PET Study.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Noha N NassarDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt.
Abdel A Abdel-RahmanDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, NC, USA.
Cairo University · EGEast Carolina University · US

Funding

Negative Impact of Alcohol on Cardiovascular NeurobiologyR01AA007839 · NIAAA · EAST CAROLINA UNIVERSITY · PI ABDEL-RAHMAN, ABDEL A · 1995 to 2011
$3.7M
NIAAA NIH HHS R01 AA007839
6 · The paper itself

Abstract

Adenosine is implicated in the modulation of cardiovascular responses either at the peripheral or at central level in experimental animals. However, there are no dedicated reviews on the involvement of adenosine in mediating the hypotensive response of centrally administered clonidine in general and specifically in aortically barodenervated rats (ABD). The conscious ABD rat model exhibits surgically induced baroreflex dysfunction and exaggerated hypotensive response, compared with conscious sham-operated (SO) rats. The current review focuses on, the role of adenosine receptors in blood pressure (BP) regulation and their possible crosstalk with other receptors e.g. imidazoline (I1) and alpha (α2A) adrenergic receptor (AR). The former receptor is a molecular target for clonidine, whose hypotensive effect is enhanced approx. 3-fold in conscious ABD rats. We also discussed how the balance between the brain stem adenosine A1 and A2A receptors is regulated by baroreceptors and how such balance influences the centrally mediated hypotensive responses. The use of the ABD rat model yielded insight into the downstream signaling cascades following clonidine-evoked hypotension in a surgical model of baroreflex dysfunction.

Indexed as

8-SPT, 8-(p-sulfophenyl)-theophylline. Non-selective adenosine receptor blockerA1, adenosine subtype A1 receptorA2A, adenosine subtype A2A receptorABC, avidin biotin complexABD rat, aortic barodenervated ratATP, adenosine triphosphateBP, blood pressurecAMP, cyclic adenosine monophosphateCentral adenosine receptorsCentrally mediated hypotensionCGS21680, 2-[4-[(2-carboxyethyl)phenyl]ethylaminophenyl]ethylamino]-5′-N-ethylcarboxamidoadenosine. Selective A2A receptor agonistClonidineCNS, central nervous systemConscious ratsCPA, N6-cyclopentyladenosine. Selective A1 receptor agonistDAG, diacylglycerolDPCPX, 8-cyclopentyl-1,3-dipropylxanthine. Selective A1 receptor antagonistERK1/2, extracellular signal regulated kinaseI1, imidazoline subtype 1 receptorI.C., intracisternalImidazoline I1-receptorIP3, Inositol TriphosphateI.V., intravenousJNK, C-Jun N-terminal kinaseL-NAME, Nω-nitro-l-arginine methyl ester hydrochloride. Non-selective nitric oxide synthase inhibitorMAPK-NOS signalingNO, nitric oxideNOS, nitric oxide synthaseNTS, nucleus tractus solitariusPC12 cells, pheochromocytoma cellsPC-PLC, phosphatidyl choline-selective phospholipase CPD98059, selective extracellular signal regulated kinase inhibitorPDE, phosphodiesterasePKA, protein kinase ARVLM, rostral ventrolateral medullaSAPK, stress activated protein kinaseSCH58261, 5-amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo[4,3-[Formula: see text]]-1,2,4-triazolo[1,5-c]pyrimidine. Selective adenosine A2A antagonistSHR, spontaneously hypertensive ratSND, sympathetic neuronal dischargeSO, sham operated = conscious normotensive ratsWKY, Wistar Kyoto ratα2 AR, alpha 2 adrenergic receptorαMNE, alpha methyl norepinephrine

Identifiers

PMID26257930
PMCPMC4522583
OpenAlexW2074978118

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.