Evidence map›Paper›PMID 26257918›Full record

ArticleBiomaterials research2015

Evaluation of ciprofloxacin and metronidazole encapsulated biomimetic nanomatrix gel on

Sagar N Kaushik, Jessica Scoffield, Adinarayana Andukuri, Grant C Alexander, Taneidra Walker, Seokgon Kim, Sung Chul Choi, Brigitta C Brott, Paul D Eleazer, Jin-Yong Lee and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Sagar N KaushikDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Jessica ScoffieldDepartment of Pediatric Dentistry, University of Alabama at Birmingham, SDB 304B, 1720 2nd Ave S, Birmingham, AL 35294-0007, USA.
Adinarayana AndukuriDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Grant C AlexanderDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Taneidra WalkerDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Seokgon KimDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
Sung Chul ChoiDepartment of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
Brigitta C BrottCardiovascular Division, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Paul D EleazerDepartment of Endodontics, University of Alabama at Birmingham, Birmingham, AL, USA.
Jin-Yong LeeDepartment of Maxillofacial Biomedical Engineering, Kyung Hee University, Seoul, Korea.
Hui WuDepartment of Pediatric Dentistry, University of Alabama at Birmingham, SDB 304B, 1720 2nd Ave S, Birmingham, AL 35294-0007, USA.
Noel K ChildersDepartment of Pediatric Dentistry, University of Alabama at Birmingham, SDB 304B, 1720 2nd Ave S, Birmingham, AL 35294-0007, USA.
Ho-Wook JunDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA.
Jae-Hong Park *Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA ; Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, Seoul, Korea.
Kyounga Cheon *Department of Pediatric Dentistry, University of Alabama at Birmingham, SDB 304B, 1720 2nd Ave S, Birmingham, AL 35294-0007, USA.
University of Alabama at Birmingham · USKyung Hee University · KR

Funding

Training Program in Cardiovascular PathophysiologyT32HL007918 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BALLINGER, SCOTT W. · 1999 to 2018
$3.6M
Prohealing multifunctional endothelium nanomatrix coated stentR01HL125391 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JUN, HO-WOOK · 2015 to 2019
$1.8M
NITRIC OXIDE RELEASING BIOMIMETRIC NANOMATRIX GELF OR ROOT REVITALIZATIONK08DE027401 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEON, KYOUNGA · 2017 to 2022
$798k
A hybrid nanosack for the enhanced islet engraftment in the omentumR03EB017344 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JUN, HO-WOOK · 2013 to 2014
$143k
NHLBI NIH HHS R01 HL125391NHLBI NIH HHS T32 HL007918NIBIB NIH HHS R03 EB017344NIDCR NIH HHS K08 DE027401NIDCR NIH HHS L30 DE023672
6 · The paper itself

Abstract

backgroundA triple antibiotic mixture (ciprofloxacin; CF, metronidazole; MN, and minocycline; MC) has been used for dental root canal medicaments in pulp regeneration therapy. However, tooth discolorations, cervical root fractures, and inadequate pulp-dentin formation have been reported due to the triple antibiotic regimen. Therefore, an antibiotic encapsulated biomimetic nanomatrix gel was developed to minimize the clinical limitations and maximize a natural healing process in root canal infections. In this study, minimal bacterial concentrations (MBC) of the selected antibiotics (CF and MN) were tested in 14 representative endodontic bacterial species. Then MBC of each CF and MN were separately encapsulated within the injectable self-assembled biomimetic nanomatrix gel to evaluate antibacterial level on

resultsAntibiotic concentrations lower than 0.2 µg/mL of CF and MN demonstrated antibacterial activity on the 14 endodontic species. Furthermore, 6 different concentrations of CF and MN separately encapsulated with the injectable self-assembled biomimetic nanomatrix gel demonstrated antibacterial activity on

conclusionsThese results suggest that each CF and MN encapsulated within the injectable self-assembled biomimetic nanomatrix gel demonstrated antibacterial effects, which could be effective for the root canal disinfection while eliminating MC. In the long term, the antibiotic encapsulated injectable self-assembled biomimetic nanomatrix gel can provide a multifunctional antibiotic delivery method with potential root regeneration. Further studies are currently underway to evaluate the effects of combined CF and MN encapsulated within the injectable self-assembled biomimetic nanomatrix gel on clinical samples.

Indexed as

CiprofloxacinEnterococcus faecalisInjectable self-assembled biomimetic nanomatrix gelMetronidazoleTreponema denticola

Identifiers

PMID26257918
PMCPMC4527351
OpenAlexW2025845360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.