Evidence map›Paper›PMID 26257895›Full record

ArticleTranslational neurodegeneration2015

Update on deep brain stimulation in Parkinson's disease.

Daniel Martinez-Ramirez, Wei Hu, Alberto R Bona, Michael S Okun, Aparna Wagle Shukla

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational neurodegeneration, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  8. Review
  9. Systemic effects of deep brain stimulation on synergic control in Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel Martinez-RamirezDepartment of Neurology, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, 3450 Hull Road, Gainesville, FL 32607 USA.
Wei HuDepartment of Neurology, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, 3450 Hull Road, Gainesville, FL 32607 USA.
Alberto R BonaDepartment of Neurosurgery, Psychiatry, and History, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, FL 32610 USA.
Michael S OkunDepartment of Neurology, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, 3450 Hull Road, Gainesville, FL 32607 USA ; Department of Neurosurgery, Psychiatry, and History, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, Gainesville, FL 32610 USA.
Aparna Wagle ShuklaDepartment of Neurology, University of Florida, College of Medicine, Center for Movement Disorders and Neurorestoration, 3450 Hull Road, Gainesville, FL 32607 USA.
Florida College · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) is considered a safe and well tolerated surgical procedure to alleviate Parkinson's disease (PD) and other movement disorders symptoms along with some psychiatric conditions. Over the last few decades DBS has been shown to provide remarkable therapeutic effect on carefully selected patients. Although its precise mechanism of action is still unknown, DBS improves motor functions and therefore quality of life. To date, two main targets have emerged in PD patients: the globus pallidus pars interna and the subthalamic nucleus. Two other targets, the ventralis intermedius and zona incerta have also been selectively used, especially in tremor-dominant PD patients. The main indications for PD DBS have traditionally been motor fluctuations, debilitating medication induced dyskinesias, unpredictable "off time" state, and medication refractory tremor. Medication refractory tremor and intolerable dyskinesia are potential palliative indications. Besides aforementioned targets, the brainstem pedunculopontine nucleus (PPN) is under investigation for the treatment of ON-state freezing of gait and postural instability. In this article, we will review the most recent literature on DBS therapy for PD, including cutting-edge advances and data supporting the role of DBS in advanced neural-network modulation.

Indexed as

Brain modulationClosed-loopGlobus pallidusMovement disordersNeural networkSubthalamic nucleus

Identifiers

PMID26257895
PMCPMC4529685
OpenAlexW2151241503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.