ArticleFrontiers in psychology2015
Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients.
Article in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Music-based interventions for chronic pain management.The Cochrane database of systematic reviews · 2026Pooled it
- Shared cortical characteristics in major depressive disorder, anxiety disorder, and chronic pain: a structural MRI meta-analysis study.Translational psychiatry · 2025Pooled it
- The effects of music & auditory beat stimulation on anxiety: A randomized clinical trial.PloS one · 2022Trial
- Tune out pain: Agency and active engagement predict decreases in pain intensity after music listening.PloS one · 2022Trial
- A Brief Music App to Address Pain in the Emergency Department: Prospective Study.Journal of medical Internet research · 2020Trial
- Compressing the lumbar nerve root changes the frequency-associated cerebral amplitude of fluctuations in patients with low back/leg pain.Scientific reports · 2019Trial
- Music induced happy mood suppresses the neural responses to other's pain: Evidences from an ERP study.Scientific reports · 2017Trial
- A scoping review of music-based pain treatment mechanism research.Pain reports · 2026Review
- Potential Effects of Music on Non-Motor Symptoms in Parkinson's Disease: Translating Mechanisms to Therapy.Neurology international · 2026Review
- Abnormal Resting-State Functional Connectivity Between the Dorsal Anterior Cingulate Cortex and the Limbic System Contributes to Pain and Emotion Regulation Impairment in Fibromyalgia Patients.International journal of rheumatic diseases · 2026Article
- A scoping review of music-based digital therapeutics for stress, anxiety, and depression.Frontiers in human neuroscience · 2026Review
- Initial Exploration of a Music-Based Telehealth Support for Medically-Complex Chronic Pain Patients.Journal of pain research · 2026Article
- Article
- Brain structural differences between fibromyalgia patients and healthy control subjects: a source-based morphometric study.Scientific reports · 2025Article
- Current source density and functional connectivity extracted from resting-state electroencephalography as biomarkers for chronic low back pain.Pain reports · 2025Article
- Investigating the neural correlates of the left thalamus in women with fibromyalgia: A Granger causality and voxel-based morphometry approach.SAGE open medicine · 2025Article
- Decoding pain's neural rhythm: Gamma oscillation mechanisms, therapeutic modulation, and translational challenges in pain management.Frontiers in neuroscience · 2025Review
- Altered trends of local brain function in classical trigeminal neuralgia patients after a single trigger pain.BMC medical imaging · 2024Article
- Pain is what you think: functional magnetic resonance imaging evidence toward a cognitive and affective approach for pain research.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- The Impact of Varied Music Applications on Pain Perception and Situational Pain Catastrophizing.The journal of pain · 2023Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Music reduces pain in fibromyalgia (FM), a chronic pain disease, but the functional neural correlates of music-induced analgesia (MIA) are still largely unknown. We recruited FM patients (n = 22) who listened to their preferred relaxing music and an auditory control (pink noise) for 5 min without external noise from fMRI image acquisition. Resting state fMRI was then acquired before and after the music and control conditions. A significant increase in the amplitude of low frequency fluctuations of the BOLD signal was evident in the left angular gyrus (lAnG) after listening to music, which in turn, correlated to the analgesia reports. The post-hoc seed-based functional connectivity analysis of the lAnG showed found higher connectivity after listening to music with right dorsolateral prefrontal cortex (rdlPFC), the left caudate (lCau), and decreased connectivity with right anterior cingulate cortex (rACC), right supplementary motor area (rSMA), precuneus and right precentral gyrus (rPreG). Pain intensity (PI) analgesia was correlated (r = 0.61) to the connectivity of the lAnG with the rPreG. Our results show that MIA in FM is related to top-down regulation of the pain modulatory network by the default mode network (DMN).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.