Evidence map›Paper›PMID 26257670›Full record

ArticleFrontiers in psychology2015

Self-reported sleep duration mitigates the association between inflammation and cognitive functioning in hospitalized older men.

Joseph M Dzierzewski, Yeonsu Song, Constance H Fung, Juan C Rodriguez, Stella Jouldjian, Cathy A Alessi, Elizabeth C Breen, Michael R Irwin, Jennifer L Martin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Joseph M DzierzewskiGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA ; David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Yeonsu SongGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA.
Constance H FungGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA ; David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Juan C RodriguezGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA ; David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Stella JouldjianGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA.
Cathy A AlessiGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA ; David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
Elizabeth C BreenDavid Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA ; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles Los Angeles, CA, USA.
Michael R IrwinDavid Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA ; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles Los Angeles, CA, USA.
Jennifer L MartinGeriatric Research, Education and Clinical Center, VA Greater Los Angeles Healthcare System Los Angeles, CA, USA ; David Geffen School of Medicine, University of California, Los Angeles Los Angeles, CA, USA.
VA Greater Los Angeles Healthcare System · USUniversity of California, Los Angeles · USSalk Institute for Biological Studies · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREENDALE, GAIL A · 2006 to 2017
$9.8M
A Dyadic Telehealth Program to Support Alzheimer’s Disease Patients and Their Caregivers During COVID-19K23AG055668 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SONG, YEONSU · 2017 to 2022
$1.1M
Improving Older Adults' Decision Making For Obstructive Sleep Apnea TreatmentK23AG045937 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FUNG, CONSTANCE · 2013 to 2017
$786k
Sleep-related predictors of function and health among vulnerable older peopleK23AG028452 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTIN, JENNIFER L · 2007 to 2009
$405k
NCATS NIH HHS UL1 TR000124NIA NIH HHS K23 AG028452NIA NIH HHS K23 AG045937NIA NIH HHS K23 AG055668NIA NIH HHS P30 AG028748
6 · The paper itself

Abstract

Examination of predictors of late-life cognitive functioning is particularly salient in at-risk older adults, such as those who have been recently hospitalized. Sleep and inflammation are independently related to late-life cognitive functioning. The potential role of sleep as a moderator of the relationship between inflammation and global cognitive functioning has not been adequately addressed. We examined the relationship between self-reported sleep duration, inflammatory markers, and general cognitive functioning in hospitalized older men. Older men (n = 135; Mean age = 72.9 ± 9.7 years) were recruited from inpatient rehabilitation units at a VA Medical Center to participate in a cross-sectional study of sleep. Participants completed the Mini-Mental State Examination and Pittsburgh Sleep Quality Index, and underwent an 8 a.m. blood draw to measure inflammatory markers [i.e., C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), soluble intercellular adhesion molecule-1 (sICAM-1), and interleukin-6 (IL-6)]. Hierarchical regression analyses (controlling for age, education, race, depression, pain, health comorbidity, and BMI) revealed that higher levels of CRP and sICAM are associated with higher global cognitive functioning in older men with sleep duration ≥6 h (β = -0.19, β = -0.18, p's < 0.05, respectively), but not in those with short sleep durations (p's > 0.05). In elderly hospitalized men, sleep duration moderates the association between inflammation and cognitive functioning. These findings have implications for the clinical care of older men within medical settings.

Indexed as

cognitionhospitalizationinflammationolder adultssleep duration

Identifiers

PMID26257670
PMCPMC4508491
OpenAlexW1948437909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.