ArticleFrontiers in human neuroscience2015
Fear avoidance beliefs in back pain-free subjects are reflected by amygdala-cingulate responses.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Effect of Multi-Modal Therapies for Kinesiophobia Caused by Musculoskeletal Disorders: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Task modulated brain connectivity of the amygdala: a meta-analysis of psychophysiological interactions.Brain structure & function · 2017Pooled it
- Pain-Affective Disorder Comorbidity in the Temporomandibular Disorders: From Mechanistic Insights to Clinical Management.Neuroscience bulletin · 2026Review
- Exploring the associations of cortical connectivity-modulation with clinical and psychological measures in acute low back pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Article
- The effect of fear of movement on gait characteristics in patients with knee osteoarthritis.BMC musculoskeletal disorders · 2025Article
- An Investigation of the Nature of Fear within ACL-Injured Subjects When Exposed to Provocative Videos: A Concurrent Qualitative and Quantitative Study.Sports (Basel, Switzerland) · 2022Article
- Article
- Recommendations for the Development of Socioeconomically-Situated and Clinically-Relevant Neuroimaging Models of Pain.Frontiers in neurology · 2021Article
- Regional increases in brain signal variability are associated with pain intensity reductions following repeated eccentric exercise bouts.European journal of pain (London, England) · 2020Article
- The Science of Auricular Microsystem Acupuncture: Amygdala Function in Psychiatric, Neuromusculoskeletal, and Functional Disorders.Medical acupuncture · 2019Article
- Brain Mechanisms of Anticipated Painful Movements and Their Modulation by Manual Therapy in Chronic Low Back Pain.The journal of pain · 2018Article
- Advancing imaging technologies for patients with spinal pain: with a focus on whiplash injury.The spine journal : official journal of the North American Spine Society · 2018Review
- Fear of pain in children and adolescents with neuropathic pain and complex regional pain syndrome.Pain · 2016Article
- Neural Correlates of Fear of Movement in Patients with Chronic Low Back Pain vs. Pain-Free Individuals.Frontiers in human neuroscience · 2016Article
- Differential Neural Processing during Motor Imagery of Daily Activities in Chronic Low Back Pain Patients.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most individuals suffering from chronic low back pain, psychosocial factors, specifically fear avoidance beliefs (FABs), play central roles in the absence of identifiable organic pathology. On a neurobiological level, encouraging research has shown brain system correlates of somatic and psychological factors during the transition from (sub) acute to chronic low back pain. The characterization of brain imaging signatures in pain-free individuals before any injury will be of high importance regarding the identification of relevant networks for low back pain (LBP) vulnerability. Fear-avoidance beliefs serve as strong predictors of disability and chronification in LBP and current research indicates that back pain related FABs already exist in the general and pain-free population. Therefore, we aimed at investigating possible differential neural functioning between high- and low fear-avoidant individuals in the general population using functional magnetic resonance imaging. Results revealed that pain-free individuals without a history of chronic pain episodes could be differentiated in amygdala activity and connectivity to the pregenual anterior cingulate cortex by their level of back pain related FABs. These results shed new light on brain networks underlying psychological factors that may become relevant for enhanced disability in a future LBP episode.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.