Evidence map›Paper›PMID 26257623›Full record

ArticleFrontiers in human neuroscience2015

Recovery of post stroke proximal arm function, driven by complex neuroplastic bilateral brain activation patterns and predicted by baseline motor dysfunction severity.

Svetlana Pundik, Jessica P McCabe, Ken Hrovat, Alice Erica Fredrickson, Curtis Tatsuoka, I Jung Feng, Janis J Daly

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

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  18. Therapeutic Applications of BCI Technologies.Brain computer interfaces (Abingdon, England) · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Svetlana PundikDepartment of Neurology, Case Western Reserve University School of Medicine Cleveland, OH, USA ; Neurology Service, Cleveland VA Medical Center Cleveland, OH, USA.
Jessica P McCabeNeurology Service, Cleveland VA Medical Center Cleveland, OH, USA.
Ken HrovatNeurology Service, Cleveland VA Medical Center Cleveland, OH, USA.
Alice Erica FredricksonNeurology Service, Cleveland VA Medical Center Cleveland, OH, USA.
Curtis TatsuokaDepartment of Neurology, Case Western Reserve University School of Medicine Cleveland, OH, USA ; Department of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA.
I Jung FengDepartment of Epidemiology and Biostatistics, Case Western Reserve University Cleveland, OH, USA.
Janis J DalyDepartment of Neurology, College of Medicine, University of Florida Gainsville, FL, USA ; North Florida/South Georgia, Gainesville VA Medical Center, Brain Rehabilitation Research Center Gainsville, FL, USA.
Louis Stokes Cleveland VA Medical Center · USCase Western Reserve University · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesNeuroplastic changes that drive recovery of shoulder/elbow function after stroke have been poorly understood. The purpose of this study was to determine the relationship between neuroplastic brain changes related to shoulder/elbow movement control in response to treatment and recovery of arm motor function in chronic stroke survivors.

methodsTwenty-three chronic stroke survivors were treated with 12 weeks of arm rehabilitation. Outcome measures included functional Magnetic Resonance Imaging (fMRI) for the shoulder/elbow components of reach and a skilled motor function test (Arm Motor Abilities Test, AMAT), collected before and after treatment.

resultsWe observed two patterns of neuroplastic changes that were associated with gains in motor function: decreased or increased task-related brain activation. Those with significantly better motor function at baseline exhibited a decrease in brain activation in response to treatment, evident in the ipsilesional primary motor and contralesional supplementary motor regions; in contrast, those with greater baseline motor impairment, exhibited increased brain activation in response to treatment. There was a linear relationship between greater functional gain (AMAT) and increased activation in bilateral primary motor, contralesional primary and secondary sensory regions, and contralesional lateral premotor area, after adjusting for baseline AMAT, age, and time since stroke.

conclusionsRecovery of functional reach involves recruitment of several contralesional and bilateral primary motor regions. In response to intensive therapy, the direction of functional brain change (i.e., increase or decrease in task-related brain recruitment) for shoulder/elbow reach components depends on baseline level of motor function and may represent either different phases of recovery or different patterns of neuroplasticity that drive functional recovery.

Indexed as

chronic strokefunctional Magnetic Resonance Imagingmotor learningmotor recoverymotor rehabilitationneuroplasticityshoulder/elbow movement taskupper extremity motor function

Identifiers

PMID26257623
PMCPMC4510426
OpenAlexW1518987196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.