ArticleFrontiers in behavioral neuroscience2015
Wired for motherhood: induction of maternal care but not maternal aggression in virgin female CD1 mice.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026Review
- Killing behaviors in rodents: from predation to infanticide.Frontiers in behavioral neuroscience · 2026Review
- Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism.Translational psychiatry · 2025Article
- Activation of the tail of the ventral tegmental area in response to pup predicting cues in maternal rats.Brain structure & function · 2025Article
- Hormonal and structural transformations in the caregiver's brain: Examining themes in parental neurobiology.AIMS neuroscience · 2025Review
- Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.Frontiers in neuroendocrinology · 2025Review
- Brain aromatase and its relationship with parental experience and behavior in male mice.Frontiers in neuroscience · 2025Article
- Role of sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus on maternal behavior.Peptides · 2024Review
- The parenting hub of the hypothalamus is a focus of imprinted gene action.PLoS genetics · 2023Article
- Effects of maternal social isolation on adult rodent offspring cognition.Scientific reports · 2023Article
- Article
- Mother-Young Bonding: Neurobiological Aspects and Maternal Biochemical Signaling in Altricial Domesticated Mammals.Animals : an open access journal from MDPI · 2023Review
- Inhibition of the medial amygdala disrupts escalated aggression in lactating female mice after repeated exposure to male intruders.Communications biology · 2022Article
- Becoming a mother shifts the activity of the social and motivation brain networks in mice.iScience · 2022Article
- Precise and Pervasive Phasic Bursting in Locus Coeruleus during Maternal Behavior in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Article
- Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.Behavioural brain research · 2021Article
- The Effect of Behavioural Indicators of Calf Discomfort Following Routine Procedures on Cow Maternal Care.Animals : an open access journal from MDPI · 2020Article
- Pregnancy Changes the Response of the Vomeronasal and Olfactory Systems to Pups in Mice.Frontiers in cellular neuroscience · 2020Article
- Placental genotype affects early postpartum maternal behaviour.Royal Society open science · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virgin adult female mice display nearly spontaneous maternal care towards foster pups after a short period of sensitization. This indicates that maternal care is triggered by sensory stimulation provided by the pups and that its onset is largely independent on the physiological events related to gestation, parturition and lactation. Conversely, the factors influencing maternal aggression are poorly understood. In this study, we sought to characterize two models of maternal sensitization in the outbred CD1 strain. To do so, a group of virgin females (godmothers) were exposed to continuous cohabitation with a lactating dam and their pups from the moment of parturition, whereas a second group (pup-sensitized females), were exposed 2 h daily to foster pups. Both groups were tested for maternal behavior on postnatal days 2-4. Godmothers expressed full maternal care from the first test. Also, they expressed higher levels of crouching than dams. Pup-sensitized females differed from dams in all measures of pup-directed behavior in the first test, and expressed full maternal care after two sessions of contact with pups. However, both protocols failed to induce maternal aggression toward a male intruder after full onset of pup-directed maternal behavior, even in the presence of pups. Our study confirms that adult female mice need a short sensitization period before the onset of maternal care. Further, it shows that pup-oriented and non-pup-oriented components of maternal behavior are under different physiological control. We conclude that the godmother model might be useful to study the physiological and neural bases of the maternal behavior repertoire.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.