Evidence map›Paper›PMID 26257600›Full record

ArticleFrontiers in neuroscience2015

Cortical iron regulation and inflammatory response in Alzheimer's disease and APPSWE/PS1ΔE9 mice: a histological perspective.

Mark D Meadowcroft, James R Connor, Qing X Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  14. Observational
  15. Iron and Alzheimer's Disease: From Pathology to Imaging.Frontiers in human neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mark D MeadowcroftDepartment of Neurosurgery, Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA ; Department of Radiology (The Center for NMR Research), Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA.
James R ConnorDepartment of Neurosurgery, Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA.
Qing X YangDepartment of Neurosurgery, Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA ; Department of Radiology (The Center for NMR Research), Milton S. Hershey Medical Center, The Pennsylvania State University - College of Medicine Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · US

Funding

Neuroimaging Study on Function-Structure Relationship of Olfactory Deficit in ADR01AG027771 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI YANG, QING X · 2008 to 2011
$1.2M
Micro-histological MRI of White Matter Cytoarchitecture in Alzheimers DiseaseR03AG047461 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MEADOWCROFT, MARK DAVID · 2014 to 2015
$158k
NIA NIH HHS R01 AG027771NIA NIH HHS R03 AG047461
6 · The paper itself

Abstract

Disruption of iron homeostasis and increased glial response are known to occur in brains afflicted by Alzheimer's disease (AD). While the APP/PS1 transgenic mouse model recapitulates the hallmark amyloid-beta plaque pathology of AD, it does so in a different neuronal mileu than humans. Understanding the iron characteristics and glial response of the APP/PS1 model is important when testing new treatment procedures and translating these results. Brain tissue from AD patients, APP/PS1 mice, and controls were stained for iron, H- and L-ferritin, microglia, astrocytes, Aβ40∕42, and degenerating neurons. The histological data demonstrate differences in ferritin, iron distribution, gliosis, and Aβ plaque composition between APP/PS1 and AD tissue. Specifically, an association between focal iron deposition and Aβ plaques is found ubiquitously throughout the AD tissue and is not observed in the APP/PS1 mouse model. Ferritin, microglia, and astrocyte staining show differential response patterns to amyloid plaques in AD and the APP/PS1 tissue. Aβ 40 and 42 antibody and thioflavin staining demonstrate morphological differences in plaque composition. The histological data support the hypothesis that iron distribution, iron management, and glial response histologically differ between the APP/PS1 and AD brain. Acknowledging the caveat that there are distinct plaque, iron, and glial contrasts between the AD brain and the APP/PS1 mouse is crucial when utilizing this model.

Indexed as

Alzheimer's diseaseamyloid-beta plaquesAPP/PS1astrocyteferritinhistologyironmicroglia

Identifiers

PMID26257600
PMCPMC4511841
OpenAlexW2118048675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.