ReviewNeuropsychiatric disease and treatment2015
Bridging the gap between education and appropriate use of benzodiazepines in psychiatric clinical practice.
Review in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Is there a link between the use of benzodiazepines and related drugs and dementia? A systematic review of reviews.European geriatric medicine · 2022Pooled it
- Benzodiazepines for antipsychotic-induced tardive dyskinesia.The Cochrane database of systematic reviews · 2018Pooled it
- Acute treatment residual depression symptoms and functional impairment among depressive patients of different age groups and education levels in China: A prospective, multicenter, randomized study.Brain and behavior · 2024Trial
- Global Trends in Deprescribing Benzodiazepine Receptor Agonists in Older Adults: A Dual-Database Bibliometric and Visual Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Optimizing Benzodiazepine Use for Chronic Insomnia: Insights from a Delphi Expert Consensus Study.Neuropsychiatric disease and treatment · 2026Article
- Synergistic Sedative Activity of Indirubin on Diazepam in Thiopental Sodium-induced Sleeping Mice: A Potential GABAergic Transmission.Molecular neurobiology · 2025Article
- Attitudes of Australian patients receiving inpatient mental health care towards deprescribing: a cross-sectional survey.BMC psychiatry · 2025Article
- Article
- Medication use in Poland for children and adolescents with neurodevelopmental disorders: before, during and after the COVID-19 pandemic - a retrospective pharmacoepidemiological study using national reimbursement data.Frontiers in pharmacology · 2025Article
- Foundations for a Personalized Psycho-Oncology: The State of the Art.Journal of personalized medicine · 2024Review
- Factors associated with the use of benzodiazepine and opioid prescription drug in the student population: a cross-sectional study.Scientific reports · 2024Article
- Benzodiazepine Use and the Risk of Dementia in the Elderly Population: An Umbrella Review of Meta-Analyses.Journal of personalized medicine · 2023Review
- Alprazolam-related deaths in Scotland, 2004-2020.Journal of psychopharmacology (Oxford, England) · 2022Article
- The association between benzodiazepine use and greater risk of neurocognitive impairment is moderated by medical burden in people with HIV.Journal of neurovirology · 2022Article
- Acute Efficacy and Safety of Escitalopram Versus Desvenlafaxine and Vortioxetine in the Treatment of Depression With Cognitive Complaint: A Rater-Blinded Randomized Comparative Study.Psychiatry investigation · 2022Article
- First-trimester exposure to benzodiazepines and risk of congenital malformations in offspring: A population-based cohort study in South Korea.PLoS medicine · 2022Observational
- Case report: Chronological symptom profile after cessation of overdose zolpidem in a patient with comorbid bipolar disorder-from anxiety, craving, paresthesia and influenza-like symptoms to seizures and hallucinations.Frontiers in psychiatry · 2022Article
- Experiences with benzodiazepine use, tapering, and discontinuation: an Internet survey.Therapeutic advances in psychopharmacology · 2022Article
- Can oral formulation increase the risk of lormetazepam abuse?Internal and emergency medicine · 2021Article
- PTSD symptoms in healthcare workers facing the three coronavirus outbreaks: What can we expect after the COVID-19 pandemic.Psychiatry research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
More than half a century after their discovery, benzodiazepines (BDZs) still represent one of the largest and most widely prescribed groups of psychotropic compounds, not only in clinical psychiatry but also in the entire medical field. Over the last two decades, however, there has been an increased focus on the development of antidepressants and antipsychotics on the part of the pharmaceutical industry, clinicians, and researchers, with a reduced interest in BDZs, in spite of their widespread clinical use. As a consequence, many psychiatric residents, medical students, nurses, and other mental health professionals might receive poor academic teaching and training regarding these agents, and have the false impression that BDZs represent an outdated chapter in clinical psychopharmacology. However, recent advances in the field, including findings concerning epidemiology, addiction risk, and drug interactions, as well as the introduction of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition with related diagnostic changes, strongly encourage an updated appraisal of the use of BDZs in clinical practice. During a recent thematic event convened with the aim of approaching this topic in a critical manner, a group of young Italian psychiatrists attempted to highlight possible flaws in current teaching pathways, identify the main clinical pros and cons regarding current use of BDZs in clinical practice, and provide an updated overview of their use across specific clinical areas and patient populations. The main results are presented and discussed in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.