ArticleAngewandte Chemie (International ed. in English)2015
Minimal synthetic cells to study integrin-mediated adhesion.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Membrane-Associated Biomolecules for Synthetic Cell Signalling.Chembiochem : a European journal of chemical biology · 2026Review
- Force Transmission by Minimal Focal Adhesion Complexes Induces Synthetic Cell Deformation.ACS synthetic biology · 2026Article
- Integrin-Functionalised Giant Unilamellar Vesicles via Gel-Assisted Formation: Good Practices and Pitfalls.International journal of molecular sciences · 2021Article
- Differential Modulation of Platelet Adhesion and Spreading by Adhesive Ligand Density.Nano letters · 2019Article
- Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes.PloS one · 2019Article
- Tuning RGD Motif and Hyaluronan Density to Study Integrin Binding.Frontiers in physiology · 2018Article
- Sequential bottom-up assembly of mechanically stabilized synthetic cells by microfluidics.Nature materials · 2018Article
- Impact of surface wettability on S-layer recrystallization: a real-time characterization by QCM-D.Beilstein journal of nanotechnology · 2017Article
- Integrative systems and synthetic biology of cell-matrix adhesion sites.Cell adhesion & migration · 2016Review
- Application of synthetic biology approaches for understanding encounters between cells and their microenvironment.Cell adhesion & migration · 2016Article
- Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches.Cell adhesion & migration · 2016Review
- Controlled Immobilization Strategies to Probe Short Hyaluronan-Protein Interactions.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
To shed light on cell-adhesion-related molecular pathways, synthetic cells offer the unique advantage of a well-controlled model system with reduced molecular complexity. Herein, we show that liposomes with the reconstituted platelet integrin αIIb β3 as the adhesion-mediating transmembrane protein are a functional minimal cell model for studying cellular adhesion mechanisms in a defined environment. The interaction of these synthetic cells with various extracellular matrix proteins was analyzed using a quartz crystal microbalance with dissipation monitoring. The data indicated that integrin was functionally incorporated into the lipid vesicles, thus enabling integrin-specific adhesion of the engineered liposomes to fibrinogen- and fibronectin-functionalized surfaces. Then, we were able to initiate the detachment of integrin liposomes from these surfaces in the presence of the peptide GRGDSP, a process that is even faster with our newly synthesized peptide mimetic SN529, which specifically inhibits the integrin αIIb β3 .
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.