Evidence map›Paper›PMID 26257170›Full record

ArticleCell reports2015

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.

Xinfang Huang, Jingjing Li, Stephanie Dorta-Estremera, Jeremy Di Domizio, Scott M Anthony, Stephanie S Watowich, Daniel Popkin, Zheng Liu, Philip Brohawn, Yihong Yao and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  4. Review
  5. The phenotype of CD3-CD56Reumatologia · 2022
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  7. Activation status of CD56Clinical rheumatology · 2021
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  8. Cellular aspects of the pathogenesis of lupus nephritis.Current opinion in rheumatology · 2021
    Review
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  11. Article
  12. Atherosclerosis in Rheumatoid Arthritis: Promoters and Opponents.Clinical reviews in allergy & immunology · 2020
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Xinfang HuangDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Rheumatology, Renji Hospital, Shanghai Institute of Rheumatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China.
Jingjing LiDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Stephanie Dorta-EstremeraDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Jeremy Di DomizioDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Scott M AnthonyDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Stephanie S WatowichDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Daniel PopkinDepartment of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA.
Zheng LiuMedImmune, LLC, Gaithersburg, MD 20878, USA.
Philip BrohawnMedImmune, LLC, Gaithersburg, MD 20878, USA.
Yihong YaoMedImmune, LLC, Gaithersburg, MD 20878, USA.
Kimberly S SchlunsDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
Lewis L LanierDepartment of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Wei CaoDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: wei.cao.phd@gmail.com.
The University of Texas MD Anderson Cancer Center · USCase Western Reserve University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
NK MemoryR01AI068129 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANIER, LEWIS LEE · 2006 to 2020
$6.0M
Receptors Of Plasmacytoid Dendritic Cells And Their LigandsR01AI074809 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CAO, WEI · 2007 to 2011
$1.9M
NCI NIH HHS CA016672NCI NIH HHS P30 CA016672NIAID NIH HHS AI068129NIAID NIH HHS AI074809NIAID NIH HHS R01 AI068129NIAID NIH HHS R01 AI074809
6 · The paper itself

Abstract

Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK) cells. IFN-α/β produced by pDCs activated NK cells via IL-15 induction. Neutrophils released reactive oxygen species (ROS), which negatively modulated the levels of IL-15, thereby inhibiting IFN-γ production. Mice deficient in NADPH oxidase 2 produced increased amounts of IFN-γ and developed augmented titers of autoantibodies. Both the pDC-IFN-α/β pathway and IFN-γ were indispensable in stimulating humoral autoimmunity. Male NZB/W F1 mice expressed higher levels of superoxide than their female lupus-prone siblings, and depletion of neutrophils resulted in spontaneous NK cell and autoimmune B cell activation. Our findings suggest a regulatory role for neutrophils in vivo and highlight the importance of an NK-IFN-γ axis downstream of the pDC-IFN-α/β pathway in systemic autoimmunity.

Indexed as

AutoimmunityImmunity, HumoralAnimalsB-LymphocytesDendritic CellsFemaleInterferon-gammaInterleukin-15Killer Cells, NaturalLupus Erythematosus, SystemicMaleMiceMice, Inbred BALB CMice, Inbred C57BLNeutrophilsReactive Oxygen SpeciesInterferon-gammaInterleukin-15Reactive Oxygen Species

Identifiers

PMID26257170
PMCPMC4545388
OpenAlexW1954738310

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.