ArticlePsychopharmacology2015
Cue reactivity and its relation to craving and relapse in alcohol dependence: a combined laboratory and field study.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 142 citations in OpenAlex.
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Effects of varenicline on alcohol cue reactivity in heavy drinkers.Psychopharmacology · 2017Trial
- Impact of alcohol-promoting and alcohol-warning advertisements on alcohol consumption, affect, and implicit cognition in heavy-drinking young adults: A laboratory-based randomized controlled trial.British journal of health psychology · 2017Trial
- Expert panel to identify applications of virtual reality (VR) in cognitive behavioral therapy for alcohol use disorder: A Delphi study.Research square · 2026Article
- Autonomic nervous system reactivity to alcohol-related cues in cocaine use disorder: vagal-sympathetic balance and clinical implications.Psychopharmacology · 2026Article
- Multimodal Psychophysiological Assessment of Craving in Patients With Alcohol Dependence During Virtual Reality Cue Exposure: Exploratory Single-Arm Clinical Study.JMIR serious games · 2026Article
- Context-Dependent Extinction and Return of Pavlovian Alcohol-Seeking Behavior in Male and Female Rats.Alcohol, clinical & experimental research · 2026Article
- The impact of anti-craving medication on cue reactivity and abstinence in patients undergoing alcohol detoxification: some preliminary evidence from a retrospective event-related potentials study.Psychopharmacology · 2026Article
- Alcohol Craving and Cue Exposure in Real Time: A Pilot Ecological Momentary Assessment (EMA)-Based Personalized Feedback Intervention for Young Adults.Journal of studies on alcohol and drugs · 2026Article
- Motivation, attention, and uncertainty: insights from animal and human research and implications for addiction.Frontiers in psychology · 2026Review
- Modification of inhibitory control and craving through transcranial direct current stimulation as an add-on treatment for substance use disorder: protocol for a randomized controlled study.BMC psychology · 2025Article
- GLP-1 agonists: a game changer in pain treatment and addiction.Pain management · 2025Review
- Development and validation of an open-source virtual reality environment for alcohol use disorder and determinants of cue-induced craving among Indian participants.Indian journal of psychiatry · 2025Article
- Differential reductions in alcohol consumption and cue-induced alcohol-seeking behavior following mGlu5 receptor inhibition in the prelimbic vs. infralimbic subregions of the rat prefrontal cortex.Pharmacology, biochemistry, and behavior · 2025Article
- Wanting and liking of Facebook functions and their correlation to problematic use.Scientific reports · 2025Article
- New Approaches for Alcohol Use Disorder Treatment via Memory Retrieval and Reconsolidation Manipulations.Current topics in behavioral neurosciences · 2025Review
- Translation Effectiveness of Offset Heart Rate Biofeedback as a Mindless Intervention for Alcohol Craving Among Risky Drinkers: Controlled Experiment.JMIR formative research · 2024Article
- Associative memory in alcohol-related contexts: An fMRI study with young binge drinkers.Journal of psychopharmacology (Oxford, England) · 2024Article
- Advising patients on the use of non-alcoholic beverages that mirror alcohol.Preventive medicine reports · 2024Article
- Beyond mediators: A critical review and methodological path forward for studying mechanisms in alcohol use treatment research.Alcohol, clinical & experimental research · 2024Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the nature of physiological cue reactivity and craving in response to alcohol cues among alcohol-dependent patients (N = 80) who were enrolled in detoxification treatment. Further, the predictive value with regard to future drinking of both the magnitude of the physiological and craving response to alcohol cues while in treatment and the degree of alcohol-cue exposure in patients' natural environment was assessed. Physiological reactivity and craving in response to experimental exposure to alcohol and soft drink advertisements were measured during detoxification treatment using heart rate variability and subjective rating of craving. Following discharge, patients monitored exposure to alcohol advertisements for five consecutive weeks with a diary and were followed up with an assessment of relapse at 5 weeks and 3 months post-discharge. The results indicated that the presence of alcohol cues such as the portrayal of the drug and drinking behaviour induced physiological cue reactivity and craving. Additionally, cue reactivity and craving were positively correlated, and cue reactivity was larger for patients with shorter histories of alcohol dependence. Further, patients reported a substantial daily exposure to alcohol cues. The magnitude of cue reactivity and the craving response to alcohol cues at baseline and degree of exposure to alcohol cues in patients' natural environment did not predict relapse. It is concluded that the presence of alcohol cues such as portrayal of alcoholic beverages and drinking behaviour induces cue reactivity and craving in alcohol dependence through a conditioned appetitive response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.