Evidence map›Paper›PMID 26257141›Full record

ReviewJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2015

4D flow cardiovascular magnetic resonance consensus statement.

Petter Dyverfeldt, Malenka Bissell, Alex J Barker, Ann F Bolger, Carl-Johan Carlhäll, Tino Ebbers, Christopher J Francios, Alex Frydrychowicz, Julia Geiger, Daniel Giese and 7 more

2 registry-linked trialsOpen access · goldAbstract readReviewConsensus Statement
In one paragraph

Review in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 421 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
421citing papers in PubMed, 1 pooled it
46.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03128268 naactive not recruitingnot on this mapstarted 2018, after this paper: background citation

THE EFFECTIVENESS OF 4D IMAGE ACQUISITION AND POST-PROCESSING WITH VIOS WORKS: A Phase Design Prospective Clinical Trial to Assess 4D Software Produced by GE and Arterys for Evaluating Cardiac Disease.

TypeinterventionalSponsorNorthwell HealthRan2018 to 2023Enrolled250ConditionsCardiac DiseaseArmsImaging software for 4 dimensional images for Cardiac MRI
NCT06424171 unknown statusnot on this mapstarted 2024, after this paper: background citation

Atrial Fibrillation and the Risk of Stroke in Veteran athLETES: a Pilot Cardiac and Cerebral Magnetic Resonance Imaging Study - AFLETES-MRI

TypeobservationalSponsorUniversity of LeicesterRan2024 to 2024Enrolled64ConditionsAtrial Fibrillation, StrokeArmsCardiac and brain magnetic resonance imaging.
3 · Its place in the literature

Who cites it

421 citing papers in PubMed, 1 synthesis or guideline pooled it, 850 citations in OpenAlex.

  1. Pooled it
  2. Review
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  7. Evaluation of sigmoid sinus hemodynamics through four-dimensional flow magnetic resonance imaging in pulsatile tinnitus patients caused by sigmoid sinus wall dehiscence coexisting with idiopathic intracranial hypertension.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  8. Article
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  11. Cardiovascular magnetic resonance for therapy monitoring in cardiomyopathies.European heart journal. Imaging methods and practice · 2026
    Review
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361 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 5 countries.

Petter DyverfeldtDivision of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. petter.dyverfeldt@liu.se.
Malenka BissellDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK. malenka.bissell@cardiov.ox.ac.uk.
Alex J BarkerDepartment of Radiology, Northwestern University, Chicago, USA. alex.barker@northwestern.edu.
Ann F BolgerDivision of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. abolger@medsfgh.ucsf.edu.
Carl-Johan CarlhällDivision of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. carljohan.carlhall@liu.se.
Tino EbbersDivision of Cardiovascular Medicine, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. tino.ebbers@liu.se.
Christopher J FranciosDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA. cfrancois@uwhealth.org.
Alex FrydrychowiczKlinik für Radiologie und Nuklearmedizin, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany. alex.frydrychowicz@uksh.de.
Julia GeigerDepartment of Radiology, University Children's Hospital Zurich, Zurich, Switzerland. julia.geiger@kispi.uzh.ch.
Daniel GieseDepartment of Radiology, University Hospital of Cologne, Cologne, Germany. daniel.giese@uk-koeln.de.
Michael D HopeDepartment of Radiology, University of California San Francisco, San Francisco, CA, United States. mdhope@stanfordalumni.org.
Philip J KilnerNIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College, London, UK. p.kilner@rbht.nhs.uk.
Sebastian KozerkeInstitute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland. kozerke@biomed.ee.ethz.ch.
Saul MyersonDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK. saul.myerson@cardiov.ox.ac.uk.
Stefan NeubauerDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, UK. stefan.neubauer@cardiov.ox.ac.uk.
Oliver WiebenDepartment of Radiology, University of Wisconsin, Madison, Wisconsin, USA. owieben@wisc.edu.
Michael MarklDepartment of Radiology, Northwestern University, Chicago, USA. mmarkl@northwestern.edu.
Linköping University · SEUniversity of Oxford · GBNorthwestern University · USUniversity of Wisconsin–Madison · USInstitute for Biomedical Engineering · CHRoyal Brompton & Harefield NHS Foundation Trust · GBUniversity Children's Hospital Zurich · CHUniversity Hospital Cologne · DEUniversity of California, San Francisco · USUniversity of Lübeck · DE

Funding

Functional Cardiovascular 4D MRI in Congenital Heart DiseaseR01HL115828 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKL, MICHAEL, RIGSBY, CYNTHIA K · 2012 to 2021
$5.2M
Hemodynamic and inflammatory imaging in evaluation of abdominal aortic aneurysmsR01HL123759 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOPE, MICHAEL DOUGLAS · 2015 to 2018
$1.6M
Quantitative Hemodynamics of the Liver with 4D Flow MRIR01DK096169 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., WIEBEN, OLIVER · 2012 to 2014
$1000k
Hemodynamic Loading of the Left Ventricle and Aorta in Aortic Valve DiseaseK25HL119608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARKER, ALEXANDER J. · 2014 to 2018
$819k
British Heart Foundation FS/10/43/28415European Research Council 310612NHLBI NIH HHS K25 HL119608NHLBI NIH HHS K25HL119608NHLBI NIH HHS R01 HL115828NHLBI NIH HHS R01 HL123759NIDDK NIH HHS R01 DK096169
6 · The paper itself

Abstract

Pulsatile blood flow through the cavities of the heart and great vessels is time-varying and multidirectional. Access to all regions, phases and directions of cardiovascular flows has formerly been limited. Four-dimensional (4D) flow cardiovascular magnetic resonance (CMR) has enabled more comprehensive access to such flows, with typical spatial resolution of 1.5×1.5×1.5 - 3×3×3 mm(3), typical temporal resolution of 30-40 ms, and acquisition times in the order of 5 to 25 min. This consensus paper is the work of physicists, physicians and biomedical engineers, active in the development and implementation of 4D Flow CMR, who have repeatedly met to share experience and ideas. The paper aims to assist understanding of acquisition and analysis methods, and their potential clinical applications with a focus on the heart and greater vessels. We describe that 4D Flow CMR can be clinically advantageous because placement of a single acquisition volume is straightforward and enables flow through any plane across it to be calculated retrospectively and with good accuracy. We also specify research and development goals that have yet to be satisfactorily achieved. Derived flow parameters, generally needing further development or validation for clinical use, include measurements of wall shear stress, pressure difference, turbulent kinetic energy, and intracardiac flow components. The dependence of measurement accuracy on acquisition parameters is considered, as are the uses of different visualization strategies for appropriate representation of time-varying multidirectional flow fields. Finally, we offer suggestions for more consistent, user-friendly implementation of 4D Flow CMR acquisition and data handling with a view to multicenter studies and more widespread adoption of the approach in routine clinical investigations.

Indexed as

AortaBlood Flow VelocityCardiovascular DiseasesCardiovascular SystemConsensusCoronary CirculationHumansImage Interpretation, Computer-AssistedMagnetic Resonance AngiographyMyocardial Perfusion ImagingPredictive Value of TestsPulsatile FlowTime Factors

Identifiers

PMID26257141
PMCPMC4530492
OpenAlexW2112795878

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.