ArticleScientific reports2015
Population Landscape of Familial Cancer.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- A novel marker for predicting malignancy in patients with thyroid nodules diagnosed as AUS on initial cytology: thyroid hormone sensitivity.Frontiers in endocrinology · 2026Article
- Risk of mortality in family members of men seeking fertility assessment.Fertility and sterility · 2025Article
- Hereditary and Familial Traits in Urological Cancers and Their Underlying Genes.European urology open science · 2024Article
- Describing patterns of familial cancer risk in subfertile men using population pedigree data.Human reproduction (Oxford, England) · 2024Article
- Proactive familial cancer risk assessment: a service development study in UK primary care.BJGP open · 2023Article
- Genetic Analysis of Multiple Primary Malignant Tumors in Women with Breast and Ovarian Cancer.International journal of molecular sciences · 2023Article
- Two Distinct Deleterious Causative Variants in a Family with Multiple Cancer-Affected Patients.Advanced biomedical research · 2023Article
- Shared environment and colorectal cancer: A Nordic pedigree registry-based cohort study.International journal of cancer · 2022Article
- Sex-specific familial aggregation of cancers in Finland.Scientific reports · 2022Article
- Colorectal cancer risk in association with colorectal cancer as a second malignancy in relatives: a nationwide cohort study.BMC cancer · 2022Article
- Whole exome sequencing identifies novel germline variants of SLC15A4 gene as potentially cancer predisposing in familial colorectal cancer.Molecular genetics and genomics : MGG · 2022Article
- Identification of NID1 as a novel candidate susceptibility gene for familial non-medullary thyroid carcinoma using whole-exome sequencing.Endocrine connections · 2022Article
- Germline Variants ofCancers · 2022Article
- Review of prostate cancer genomic studies in Africa.Frontiers in genetics · 2022Review
- Article
- Family history of breast cancer as a second primary malignancy in relatives: a nationwide cohort study.BMC cancer · 2021Article
- Article
- Familial non-medullary thyroid cancer: a critical review.Journal of endocrinological investigation · 2021Review
- The role of genomics in global cancer prevention.Nature reviews. Clinical oncology · 2021Review
- The missing heritability of familial colorectal cancer.Mutagenesis · 2020Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Public perception and anxiety of familial cancer have increased demands for clinical counseling, which may be well equipped for gene testing but less prepared for counseling of the large domain of familial cancer with unknown genetic background. The aim of the present study was to highlight the full scope of familial cancer and the variable levels of risk that need to be considered. Data on the 25 most common cancers were obtained from the Swedish Family Cancer Database and a Poisson regression model was applied to estimate relative risks (RR) distinguishing between family histories of single or multiple affected first-degree relatives and their diagnostic ages. For all cancers, individual risks were significantly increased if a parent or a sibling had a concordant cancer. While the RRs were around 2.00 for most cancers, risks were up to 10-fold increased for some cancers. Familial risks were even higher when multiple relatives were affected. Although familial risks were highest at ages below 60 years, most familial cases were diagnosed at older ages. The results emphasized the value of a detailed family history as a readily available tool for individualized counseling and its preventive potential for a large domain of non-syndromatic familial cancers.
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